Targeting white matter neuroprotection as a relapse prevention strategy for treatment of cocaine use disorder: Design of a mechanism-focused randomized clinical trial.
Targeting white matter neuroprotection as a relapse prevention strategy for treatment of cocaine use disorder: Design of a mechanism-focused randomized clinical trial.
复制标题
DOI：
10.1016/j.cct.2021.106603
复制
发表时间：
2021-12
影响因子：
2.2
通讯作者：
Green CE
中科院分区：
文献类型：
--
作者：
Schmitz JM;Lane SD;Weaver MF;Narayana PA;Hasan KM;Russell DD;Suchting R;Green CE
可卡因使用仍然是一个重大的公共卫生问题，治疗选择有限，没有批准的药物治疗。认知行为疗法（CBT）仍然是预防复发的主要治疗方法，然而，长期使用可卡因的人显示出与CBT反应不良相关的认知障碍。动物和人体研究中的新证据表明，过氧化物酶体增殖物激活受体-γ（PPAR- γ）激动剂吡格列酮可改善认知功能所必需的白色物质完整性。该项目将确定连续使用吡格列酮是否增强CBT在可卡因使用障碍恢复早期预防复发的作用。本文描述了一项以机制为重点的II期随机临床试验的设计，该试验的目的首先是评估吡格列酮对与白色物质完整性、认知功能和可卡因渴求相关的靶向机制的影响;其次是评估靶向机制的改善预测CBT应答的程度。积极的结果将支持吡格列酮作为一种潜在的认知增强剂推进到后期药物开发研究。
Cocaine use continues to be a significant public health problem with limited treatment options and no approved pharmacotherapies. Cognitive-behavioral therapy (CBT) remains the mainstay treatment for preventing relapse, however, people with chronic cocaine use display cognitive impairments that are associated with poor response to CBT. Emerging evidence in animal and human studies suggests that the peroxisome proliferator-activated receptor-gamma (PPAR- γ) agonist, pioglitazone, improves white matter integrity that is essential for cognitive function. This project will determine whether adjunctive use of pioglitazone enhances the effect of CBT in preventing relapse during the early phase of recovery from cocaine use disorder. This paper describes the design of a mechanism-focused phase 2 randomized clinical trial that aims first to evaluate the effects of pioglitazone on targeted mechanisms related to white matter integrity, cognitive function, and cocaine craving; and second, to evaluate the extent to which improvements on target mechanisms predict CBT response. Positive results will support pioglitazone as a potential cognitive enhancing agent to advance to later stage medication development research.
登录
查看更多内容
影响因子：
--
作者：
Carroll, KM;Fenton, LR;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
4.2
作者：
Aharonovich, E;Hasin, DS;Nunes, EV
通讯作者：
Nunes, EV
影响因子：
4.2
作者：
Carroll, KM;Nich, C;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
4.2
作者：
DeWorsop, David;Creatura, Gina;D'Souza, Deepak Cyril
通讯作者：
D'Souza, Deepak Cyril
影响因子：
1.5
作者：
Chuang-Stein, Christy
通讯作者：
Chuang-Stein, Christy