Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory
Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory
复制标题
伏隔核中的神经元 HMGB1 调节可卡因奖赏记忆
DOI：
10.1111/adb.12739
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发表时间：
2020-03-01
影响因子：
3.4
通讯作者：
Chen, Jian-Guo
中科院分区：
文献类型：
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作者：
Gao, Shuang-Qi;Zhang, Hai;Chen, Jian-Guo
可卡因是一种常见的滥用药物，可引起中枢神经系统（CNS）突触和免疫反应异常。HMGB1 （High mobility group box 1）是一种炎症分子，在神经元和免疫细胞上均有表达。先前关于HMGB1在中枢神经系统中的研究主要集中在免疫功能上，HMGB1在神经元和可卡因成瘾中的作用尚不清楚。本研究表明，可卡因暴露诱导伏隔核（NAc）神经元中HMGB1的易位和释放。NAc中HMGB1的增加和减少双向调节可卡因诱导的条件位置偏好。从细胞核到胞质，HMGB1与谷氨酸受体亚基（GluA2/GluN2B）结合，调节可卡因诱导的突触适应和可卡因相关记忆的形成。这些数据揭示了HMGB1在神经元中的作用，并为HMGB1参与药物成瘾提供了证据。
Cocaine is a common abused drug that can induce abnormal synaptic and immune responses in the central nervous system (CNS). High mobility group box 1 (HMGB1) is one kind of inflammatory molecules that is expressed both on neurons and immune cells. Previous studies of HMGB1 in the CNS have largely focused on immune function, and the role of HMGB1 in neurons and cocaine addiction remains unknown. Here, we show that cocaine exposure induced the translocation and release of HMGB1 in the nucleus accumbens (NAc) neurons. Gain and loss of HMGB1 in the NAc bidirectionally regulate cocaine‐induced conditioned place preference. From the nucleus to the cytosol, HMGB1 binds to glutamate receptor subunits (GluA2/GluN2B) on the membrane, which regulates cocaine‐induced synaptic adaptation and the formation of cocaine‐related memory. These data unveil the role of HMGB1 in neurons and provide the evidence for the HMGB1 involvement in drug addiction.