The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell.
The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell.
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p38alpha/beta MAPK 作为分子开关来激活静止的卫星细胞。
DOI：
10.1083/jcb.200408066
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发表时间：
2005-04-11
影响因子：
7.8
通讯作者：
Olwin, BB
中科院分区：
文献类型：
--
作者：
Jones, NC;Tyner, KJ;Nibarger, L;Stanley, HM;Cornelison, DDW;Fedorov, YV;Olwin, BB
成体干细胞缓慢循环或保持静止状态，直到需要进行组织修复和维护。肌肉损伤后，位于肌纤维和基底层（卫星细胞）之间的干细胞被激活、增殖并最终分化以修复受损的肌肉。健康肌肉中的卫星细胞是静止的，不表达MyoD家族转录因子或细胞周期调节基因，并且与周围环境隔离。在这里，我们报道丝裂原激活蛋白激酶 (MAPK) 的 p38α/β 家族可逆地调节骨骼肌卫星细胞的静止状态。抑制 p38α/β MAPK (a) 促进退出细胞周期，(b) 防止分化，(c) 使细胞免受大多数外部刺激，使卫星细胞保持静止状态。卫星细胞和 p38α/β MAPK 的激活同时发生，进一步支持这些 MAPK 作为卫星细胞激活的分子开关。
Somatic stem cells cycle slowly or remain quiescent until required for tissue repair and maintenance. Upon muscle injury, stem cells that lie between the muscle fiber and basal lamina (satellite cells) are activated, proliferate, and eventually differentiate to repair the damaged muscle. Satellite cells in healthy muscle are quiescent, do not express MyoD family transcription factors or cell cycle regulatory genes and are insulated from the surrounding environment. Here, we report that the p38α/β family of mitogen-activated protein kinases (MAPKs) reversibly regulates the quiescent state of the skeletal muscle satellite cell. Inhibition of p38α/β MAPKs (a) promotes exit from the cell cycle, (b) prevents differentiation, and (c) insulates the cell from most external stimuli allowing the satellite cell to maintain a quiescent state. Activation of satellite cells and p38α/β MAPKs occurs concomitantly, providing further support that these MAPKs function as a molecular switch for satellite cell activation.
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影响因子：
7.8
作者：
Cusella-De Angelis, M G;Lyons, G;Sonnino, C;De Angelis, L;Vivarelli, E;Farmer, K;Wright, W E;Molinaro, M;Bouche, M;Buckingham, M
通讯作者：
Buckingham, M
影响因子：
2.7
作者：
Cornelison, DDW;Olwin, BB;Wold, BJ
通讯作者：
Wold, BJ
影响因子：
3.5
作者：
Eyers, PA;van den Ijssel, P;Cohen, P
通讯作者：
Cohen, P
影响因子：
2.7
作者：
Cornelison, DDW;Wold, BJ
通讯作者：
Wold, BJ
影响因子：
4.8
作者：
Morooka, T;Nishida, E
通讯作者：
Nishida, E