The "central vein sign" in inflammatory demyelination: The role of fibrillar collagen type I
The "central vein sign" in inflammatory demyelination: The role of fibrillar collagen type I
复制标题
DOI：
10.1002/ana.25461
复制
发表时间：
2019-06-01
影响因子：
11.2
通讯作者：
Reich, Daniel S.
中科院分区：
文献类型：
--
作者：
Absinta, Martina;Nair, Govind;Reich, Daniel S.
越来越多的证据证实了“中央静脉征”在多发性硬化症(MS)的放射诊断中的作用。在此，我们报告了人类磁共振成像(MRI)和相应的病理数据，即炎症依赖的脑内血管壁重塑与基于敏感性的MRI上病变内静脉的突出直接相关。在患有实验性自身免疫性脑脊髓炎的成年绒猴中，血管壁纤维化在脱髓鞘过程的早期就被检测到，甚至在病变中也是如此。
Accumulating evidence corroborates the role of the "central vein sign" in the radiological diagnosis of multiple sclerosis (MS). Here, we report human magnetic resonance imaging (MRI) and corresponding pathological data that inflammation-dependent intracerebral remodeling of the vessel wall is directly associated with the prominence of intralesional veins on susceptibility-based MRI. In adult marmosets with experimental autoimmune encephalomyelitis, vessel-wall fibrosis was detected early in the demyelinating process, even in lesions