Loss of medial septal modulation of dentate gyrus physiology in young mice overexpressing human beta-amyloid precursor protein.
Loss of medial septal modulation of dentate gyrus physiology in young mice overexpressing human beta-amyloid precursor protein.
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过度表达人β-淀粉样前体蛋白的幼鼠中齿状回生理学的内侧间隔调节丧失。
DOI：
10.1016/s0304-3940(02)00732-2
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发表时间：
2002
影响因子：
2.5
通讯作者：
Criado,JoséR
中科院分区：
文献类型：
--
作者：
Sánchez-Alavez,Manuel;Gallegos,RogerA;Kalafut,MaryA;Games,Dora;Henriksen,StevenJ;Criado,JoséR
过度表达人类突变型β淀粉样前体蛋白（hβAPP; PDAPP小鼠）的小鼠在Aβ斑块沉积之前的年龄表现出海马依赖性空间学习和海马短期和长期可塑性的缺陷。我们确定了年轻的PDAPP小鼠是否也表现出体内隔海马功能的改变，这在认知功能中起着重要作用。电刺激内侧隔显著增加神经元的兴奋性和减少配对脉冲促进齿状回。内侧隔诱导的齿状神经元兴奋性的促进作用在PDAPP小鼠中降低。在PDAPP小鼠中，内侧隔刺激对齿状配对脉冲易化的抑制作用也减弱。过度表达hβAPP的年轻小鼠表现出与认知功能有关的神经回路的早期异常，这可能在老年PDAPP小鼠中观察到的更严重的缺陷中起重要作用。
Mice overexpressing the human mutant β-amyloid precursor protein (hβAPP; PDAPP mice) show deficits in hippocampal-dependent spatial learning and hippocampal short- and long-term plasticity at ages preceding Aβ plaque deposition. We determined whether young PDAPP mice also exhibit alterations in septohippocampal function in vivo, which plays an important role in cognitive function. Electrical stimulation of the medial septum significantly increased neuronal excitability and reduced paired-pulse facilitation in the dentate gyrus. Medial septal-induced facilitation of dentate neuronal excitability was reduced in PDAPP mice. The inhibitory effects of medial septum stimulation on dentate paired-pulse facilitation were also attenuated in PDAPP mice. Young mice overexpressing hβAPP exhibit early abnormalities in neural circuits implicated in cognitive function that may play an important role in the more profound deficits observed in aged PDAPP mice.