Familial abnormalities of suppressor-cell function in systemic lupus erythematosus.
Familial abnormalities of suppressor-cell function in systemic lupus erythematosus.
复制标题
系统性红斑狼疮抑制细胞功能的家族性异常。
DOI：
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发表时间：
1979
影响因子：
158.5
通讯作者：
R. Schwartz
中科院分区：
文献类型：
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作者：
K. Miller;R. Schwartz
我们测试的假设，中枢免疫功能异常是遗传控制的系统性红斑狼疮患者。我们使用体外抑制细胞试验来评估15名患者、50名临床健康的家庭成员和41名正常人的中枢免疫调节。抑制细胞功能受损11例；疾病活动与检测结果之间没有相关性。在13名一级亲属中也发现了异常的抑制细胞活性，其中12名是女性。我们发现抑制细胞试验的结果与亲属中存在或不存在淋巴细胞毒性抗体之间没有相关性。抑制细胞功能受损本身不能解释系统性红斑狼疮的发病机制。我们的结果支持了抑制细胞的某些异常是遗传标记的假设。我们提出，系统性红斑狼疮的发展需要至少两个功能不同的基因类的参与。
We tested the hypothesis that abnormalities of central immune function are genetically controlled in patients with systemic lupus erythematosus. We used an in vitro suppressor-cell assay to evaluate central immunoregulation in 15 patients, 50 of their clinically healthy family members and 41 normal persons. Impaired suppressor-cell function was found in 11 patients; there was no correlation between disease activity and test results. Abnormal suppressor-cell activity was also found in 13 first-degree relatives, 12 of whom were women. We found no correlation between results of the suppressor-cell assay and the presence or absence of lymphocytotoxic antibodies in the relatives. Impaired suppressor-cell function cannot by itself explain the pathogenesis of systemic lupus erythematosus. Our results support the hypothesis that certain abnormalities of suppressor cells are genetic markers. We propose that the development of systemic lupus erythematosus requires the participation of at least two functionally distinct classes of genes.