Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China
Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China
复制标题
中国福氏志贺菌1c亚型对氟喹诺酮类和第三代头孢菌素耐药的出现
DOI：
10.1111/j.1469-0691.2012.03768.x
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发表时间：
2012-04-01
影响因子：
14.2
通讯作者：
Song, H.
中科院分区：
文献类型：
--
作者：
Qiu, S.;Xu, X.;Song, H.
我们在此报告中国首次鉴定出福氏志贺氏菌亚型1c。我们还报道了首次出现对环丙沙星和第三代头孢菌素耐药的1c亚血清型患者。从中国流行的7株分离株中分离出3种新的序列类型和7种脉冲场凝胶电泳图谱，表明分离株具有较高的遗传多样性。总体而言，7株菌株对环丙沙星的敏感性降低；一株对环丙沙星耐药，另一株对环丙沙星、诺氟沙星、头孢噻肟和头孢曲松耐药。
We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.