Roles of growth hormone and testosterone in the synthesis of mouse kidney glucuronidase
Roles of growth hormone and testosterone in the synthesis of mouse kidney glucuronidase
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生长激素和睾酮在小鼠肾葡萄糖醛酸酶合成中的作用
DOI：
10.1016/0303-7207(78)90110-7
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发表时间：
1978
影响因子：
4.1
通讯作者：
R. Swank
中科院分区：
文献类型：
--
作者：
R. Swank
小鼠肾脏 β-葡萄糖醛酸酶的产生受到多激素的控制。在正常小鼠中，睾酮可诱导 100 倍以上的肾脏葡萄糖醛酸酶。然而，垂体切除术将这种诱导减少到正常值的 5% 左右。这种诱导能力的丧失部分由生长激素恢复。同时给予垂体切除的雌性小鼠生长激素和睾酮，但不是催乳素和睾酮，可使肾脏葡萄糖醛酸酶浓度恢复到睾酮治疗的正常雌性小鼠的一半。单独的生长激素对垂体切除的雌性没有作用，也不能增强睾酮治疗的正常雌性的葡萄糖醛酸酶活性。放射性标记实验表明，生长激素对葡萄糖醛酸酶活性的增强伴随着其合成速率的相应增加。肾脏肥大和肾脏葡萄糖醛酸酶的产生可能受到共同的激素调节。睾酮或生长激素单独治疗垂体切除小鼠对任一过程影响很小或没有影响，但两种激素联合治疗显着增强这两个过程。肾葡萄糖醛酸酶的合成速率由Gurgene控制。在睾酮治疗的垂体切除小鼠中，不同Gurgeno型小鼠的肾脏葡萄糖醛酸酶合成的相对差异得以维持。这表明Gurlocus对葡萄糖醛酸酶合成的控制是通过与雄激素而不是垂体产物的相互作用来实现的。
Mouse kidney β-glucuronidase production is under multihormonal control. In normal mice, kidney glucuronidase is induced over 100-fold by testosterone. However, hypophysectomy reduces this induction to about 5% of normal. This loss in inducibility was in part restored by growth hormone. Simultaneous administration to hypophysectomized female mice of growth hormone and testosterone, but not of prolactin and testosterone, restored kidney glucuronidase concentration to half that found in testosterone-treated normal female mice. Growth hormone alone had no effect in hypophysectomized females nor did it enhance glucuronidase activity in testosterone-treated normal females. Radiolabeling experiments demonstrated that the enhancement by growth hormone of glucuronidase activity was accompanied by a corresponding increase in its rate of synthesis.Kidney hypertrophy and kidney glucuronidase production may be under common hormonal regulation. Testosterone or growth hormone treatment alone of hypophysectomized mice had little or no effect on either process, but combined treatment with the two hormones significantly enhanced both.The rate of synthesis of kidney glucuronidase is controlled by theGurgene. Relative differences in kidney glucuronidase synthesis in mice of differentGurgenotype were maintained in testosterone-treated hypophysectomized mice. This suggests that control of glucuronidase synthesis by theGurlocus is exerted by interaction with androgens rather than pituitary products.