Lung fluid balance in lambs before and after premature birth.
Lung fluid balance in lambs before and after premature birth.
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羔羊早产前后的肺液平衡。
DOI：
10.1172/jci114200
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Chapman,DL
中科院分区：
文献类型：
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作者：
Bland,RD;Carlton,DP;Scheerer,RG;Cummings,JJ;Chapman,DL
本研究的目的是观察早产儿呼吸窘迫的肺血管蛋白渗透性是否高于无肺病的羔羊。我们测量了10只长期插管早产羔羊（妊娠133 +/- 1天）的肺血管压力，肺淋巴流量，淋巴液和血浆中的蛋白质浓度为2-4小时前和4-8小时后剖宫产。所有羔羊出生后均接受机械通气治疗，并以每小时10 ml/kg的速率持续静脉输注葡萄糖-生理盐水溶液。6只羔羊呼吸衰竭，其中有一个持续的三倍出生后增加肺淋巴液流量和淋巴蛋白流量，胸腔积液引流的增加更大。淋巴液和胸膜液中的蛋白浓度几乎相同，平均约为血浆蛋白浓度的75%。在4只无肺部疾病的早产羔羊中，淋巴流量和淋巴蛋白流量在出生后6-8小时接近或低于胎儿值，并且很少或没有胸腔积液引流。在患有呼吸衰竭的羔羊中，血管外肺水平均为7.3 +/- .8 g/g干肺，而在没有肺病的羔羊中，血管外肺水平均为4.8 +/- .5 g/g干肺。因此，肺水肿伴随着富含蛋白质的液体从肺微循环异常渗漏到肺泡，是早产后经常发生的呼吸系统疾病的重要病理特征。图像
The purpose of this study was to see if lung vascular protein permeability is greater in preterm lambs with respiratory distress than it is in lambs without lung disease. We measured pulmonary vascular pressures, lung lymph flow, and concentrations of protein in lymph and plasma of 10 chronically catheterized preterm lambs (gestation 133 +/- 1 d) for 2-4 h before and for 4-8 h after delivery by cesarean section. All lambs were treated with mechanical ventilation after birth and received a constant intravenous infusion of glucose-saline solution at an hourly rate of 10 ml/kg. Respiratory failure developed in six lambs, in which there was a sustained threefold postnatal increase in lung lymph flow and lymph protein flow, with an even greater increase in pleural liquid drainage. Concentrations of protein in lymph and pleural liquid were almost identical, averaging approximately 75% of the plasma protein concentration. In the four preterm lambs without lung disease, lymph flow and lymph protein flow were either near or below fetal values by 6-8 h after birth, and there was little or no pleural liquid drainage. Extravascular lung water averaged 7.3 +/- .8 g/g dry lung in lambs with respiratory failure compared to 4.8 +/- .5 g/g dry lung in lambs without lung disease. Thus, pulmonary edema with abnormal leakage of protein-rich liquid from the lung microcirculation into the interstitium is an important pathological feature of the respiratory disease that often occurs after premature birth.Images