Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency
Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency
复制标题
揭示药物包埋的聚合物胶束之间的相互作用势表面，阐明药物纳米载体的高效率
DOI：
10.1021/acs.nanolett.0c03978
复制
发表时间：
2021
期刊：
影响因子：
10.8
通讯作者：
Sumi Tomonari
中科院分区：
文献类型：
--
作者：
Morita Takeshi;Mukaide Sayaka;Chen Ziqiao;Higashi Kenjirou;Imamura Hiroshi;Moribe Kunikazu;Sumi Tomonari
聚合物胶束作为药物纳米载体是非常有价值的介质。虽然胶束之间的相互作用的知识是理解的机制和开发的上级功能的关键，药物掺入的聚合物胶束之间的相互作用的潜在表面尚未定量评估由于极其复杂的结构。结合小角散射实验和无模型势液相理论，揭示了药物包埋聚合物胶束之间的相互作用势面。研究了由聚环氧乙烷和聚环氧丙烷组成的三嵌段共聚物在宽浓度范围（0.5- 10.0wt%）内的反应。通过比较有无药物的相互作用，探讨了包封水不溶性疏水性药物环孢素A对相互作用的影响。结果直接阐明了胶束之间相互作用方面的高药物载体效率。此外，基于密度泛函理论的调查提供了一个更深入的了解单体的纳米载体的极其稳定的分散体的贡献。
Polymeric micelles are invaluable media as drug nanocarriers. Although knowledge of an interaction between the micelles is a key to understanding the mechanisms and developing the superior functions, the interaction potential surface between drug-incorporated polymeric micelles has not yet been quantitatively evaluated due to the extremely complex structure. Here, the interaction potential surface between drug-entrapped polymeric micelles was unveiled by combining a small-angle scattering experiment and a model-potential-free liquid-state theory. Triblock copolymer composed of poly(ethylene oxide) and poly(propylene oxide) was investigated over a wide concentration range (0.5–10.0 wt %). Effects of the entrapment of a water-insoluble hydrophobic drug, cyclosporin A, on the interaction were explored by comparing the interactions with and without the drug. The results directly clarified the high drug carrier efficiency in terms of the interaction between the micelles. In addition, an investigation based on density functional theory provided a deeper insight into the monomer contribution to the extremely stable dispersion of the nanocarrier.