Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I-2: synthesis of [2,3]-fused indoline tetrahydropyridazines
Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I-2: synthesis of [2,3]-fused indoline tetrahydropyridazines
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I-2催化吲哚与酮和磺酰肼的分子间脱芳氧化偶联：合成[2,3]-稠合二氢吲哚四氢哒嗪
DOI：
10.1007/s11426-016-0170-8
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发表时间：
2016
影响因子：
9.6
通讯作者：
Liu Li
中科院分区：
文献类型：
--
作者：
Wei Feng;Cheng Liang;Huang Hongyan;Liu Jiejie;Wang Dong;Liu Li
通过I2/叔丁基过氧化氢（TBHP）催化吲哚、肼和苯乙酮的三组分脱芳氧化偶联反应，以中等至良好的产率合成了[2，3]-稠合吲哚啉四氢哒嗪。该方案为合成这些具有生物学意义的稠合吲哚啉提供了一种新的方法。
A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide (TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.