Eicosanoid storm in infection and inflammation.
Eicosanoid storm in infection and inflammation.
复制标题
DOI：
10.1038/nri3859
复制
发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Norris PC
中科院分区：
文献类型：
--
作者：
Dennis EA;Norris PC
对感染和损伤的受控免疫反应涉及复杂的分子信号网络，这些网络具有协调的、往往是相反的行为。二十烷基类化合物和相关的来自多不饱和脂肪酸的生物活性脂类介体构成了一个主要的生物活性脂类网络，这是在生理背景下定位最复杂和最具挑战性的途径之一。二十烷类信号类似于细胞因子信号和炎症体的形成，被认为主要是先天免疫反应的促炎成分；然而，脂类组学的最新进展有助于阐明独特的二十烷类化合物和相关的具有抗炎和促分解功能的二十二烷类化合物。这促进了我们对炎症反应及其治疗意义的整体理解。本文综述了感染性病原体通过激活炎症受体诱导促炎和抗炎二十烷酸风暴的研究进展。
Controlled immune responses to infection and injury involve complex molecular signaling networks with coordinated and often opposing actions. Eicosanoids and related bioactive lipid mediators derived from polyunsaturated fatty acids constitute a major bioactive lipid network, which is among the most complex and challenging pathways to map in a physiological context. Eicosanoid signaling, similar to cytokine signaling and inflammasome formation, has been viewed as primarily a pro-inflammatory component of the innate immune response; however, recent advances in lipidomics have helped to elucidate unique eicosanoids and related docosanoids with anti-inflammatory and pro-resolution functions. This has advanced our overall understanding of the inflammatory response and its therapeutic implications. The induction of a pro- and anti-inflammatory eicosanoid storm through the activation of inflammatory receptors by infectious agents is reviewed.