Murine segmental duplications are hot spots for chromosome and gene evolution
Murine segmental duplications are hot spots for chromosome and gene evolution
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DOI：
10.1016/j.ygeno.2005.08.008
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发表时间：
2005-12-01
期刊：
影响因子：
4.4
通讯作者：
Estivill, X
中科院分区：
文献类型：
--
作者：
Armengol, L;Marquès-Bonet, T;Estivill, X
小鼠和大鼠的基因组序列使我们能够全面了解两个物种之间发生的进化重排，并定义可能是这些事件背后的标志。我们对小鼠和大鼠基因组的序列组装进行了比较研究，并报告了在不保留同线性的区域中啮齿动物特异性片段重复的富集。我们表明，片段重复呈现出更高的分子进化率，并且重排区域中的基因比其他地方的基因进化得更快。先前的研究表明，小鼠和人类基因组之间的同线性断点在人类片段重复中丰富，表明这种结构与进化重排之间存在因果关系。我们的工作提供了进一步的证据来支持片段重复在哺乳动物染色体结构的进化以及小鼠和大鼠的物种形成过程中的染色体重排中的作用。 (c) 2005 Elsevier Inc. 保留所有权利。
Mouse and rat genomic sequences permit us to obtain a global view of evolutionary rearrangements that have occurred between the two species and to define hallmarks that might underlie these events. We present a comparative study of the sequence assemblies of mouse and rat genomes and report an enrichment of rodent-specific segmental duplications in regions where synteny is not preserved. We show that segmental duplications present higher rates of molecular evolution and that genes in rearranged regions have evolved faster than those located elsewhere. Previous studies have shown that synteny breakpoints between the mouse and the human genomes are enriched in human segmental duplications, suggesting a causative connection between such structures and evolutionary rearrangements. Our work provides further evidence to support the role of segmental duplications in chromosomal rearrangements in the evolution of the architecture of mammalian chromosomes and in the speciation processes that separate the mouse and the rat. (c) 2005 Elsevier Inc. All rights reserved.