Regulatory role of microRNAs in ovarian function
Regulatory role of microRNAs in ovarian function
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DOI：
10.1016/j.fertnstert.2014.04.024
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发表时间：
2014-06-01
影响因子：
6.7
通讯作者：
Eisenberg, Iris
中科院分区：
文献类型：
--
作者：
Imbar, Tal;Eisenberg, Iris
最近，人们开始在卵巢细胞中探索MicroRNAs，发现它们对卵巢基本特征的影响，如类固醇生成、排卵和黄体发育和功能。我们综述了microRNAs的最新研究进展，特别是与人类卵巢细胞功能和microRNAs在卵巢生理过程和排卵功能障碍中的作用有关。由于microrna在体液中已知的稳定性，我们也启发了它们在临床环境中作为卵巢功能的新型生物标志物的潜在用途。未来对microrna在生理性和功能失调排卵中的作用的研究可能为不孕症和其他卵巢疾病的诊断和治疗提供新的策略。
MicroRNAs have recently begun to be explored in ovarian cells, uncovering their influence on fundamental ovarian features like steroidogenesis, ovulation, and curpos luteum development and function. We provide a review of the current knowledge on microRNAs, specifically relating to human ovarian cell function and microRNAs' role in the ovarian physiologic process and ovulation dysfunction. Because of microRNAs' known stability in body fluids, we enlighten also their potential use in the clinical setting as novel biomarkers for ovarian function. Future research of the role of microRNAs in physiologic and dysfunctional ovulation may offer new diagnostic and treatment strategies for infertility and other ovarian disorders.