Self-Assembling Zwitterionic Copolymers as Membrane Selective Layers with Excellent Fouling Resistance: Effect of Zwitterion Chemistry
Self-Assembling Zwitterionic Copolymers as Membrane Selective Layers with Excellent Fouling Resistance: Effect of Zwitterion Chemistry
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DOI：
10.1021/acsami.7b04884
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发表时间：
2017-06-21
影响因子：
9.5
通讯作者：
Asatekin, Ayse
中科院分区：
文献类型：
--
作者：
Bengani-Lutz, Prity;Converse, Elisha;Asatekin, Ayse
通过简单的涂覆方法在多孔载体上形成选择性的自组装两性离子两亲性无规共聚物层，制备了具有高通量、孔径接近1 nm和前所未有的抗蛋白质污染性的膜。以疏水性单体甲基丙烯酸 2,2,2-三氟乙酯 (TFEMA) 和四种两性离子单体（磺基甜菜碱甲基丙烯酸酯、磺基甜菜碱 2-乙烯基吡啶、磺基丁基甜菜碱 2-乙烯基吡啶和 2-甲基丙烯酰氧基乙基磷酰胆碱）通过自由基聚合制备无规共聚物。所有共聚物微相分离，形成类似于 1.2 nm 纳米域的双连续，其中两性离子域充当水和溶质渗透的纳米通道。所得膜均具有与两性离子化学无关的纳米尺寸截止值。然而，不同两性离子单体制备的膜在亲水性、吸水率、水通量和抗污染性方面存在显着差异。由2-甲基丙烯酰氧基乙基磷酰胆碱的共聚物制备的膜最亲水，并且具有最高的透水性，高于相似孔径的商业膜。此外，这些膜表现出前所未有的抗污染能力，在 24 小时蛋白质污染实验中没有表现出可测量的通量下降。从不同两性离子结构的调查中收集到的结构特性关系可作为开发用于膜、药物输送和传感器等各种应用的新型两性离子材料的指南。
Membranes with high flux, similar to 1 nm pore size, and unprecedented protein fouling resistance were prepared by forming selective layers of self assembling zwitterionic amphiphilic random copolymers on porous supports by a simple coating method. Random copolymers were prepared from the hydrophobic monomer 2,2,2-trifluoroethyl methacrylate (TFEMA) and four zwitterionic monomers (sulfobetaine methacrylate, sulfobetaine 2-vinylpyridine, sulfobutylbetaine 2-vinylpyridine, and 2-methacryloyloxyethyl phosphorylcholine) by free radical polymerization. All copolymers microphase separated to form bicontinuous similar to 1.2 nm nanodomains with the zwitterionic domains acting as nanochannels for the permeation of water and solutes. The resultant membranes all had a nm size cutoff independent of zwitterion chemistry. There were, however, significant differences in the hydrophilicity, water uptake, water flux, and fouling resistance among membranes prepared with different zwitterionic monomers. Membranes prepared from the copolymer with 2-methacryloyloxyethyl phosphorylcholine were the most hydrophilic and had the highest water permeance, higher than that of commercial membranes of similar pore size. Furthermore, these membranes showed unprecedented fouling resistance, exhibiting no measurable flux decline throughout a 24 h protein fouling experiment. The structure property relationships gleaned from this survey of different zwitterion structures serves as a guideline to develop new zwitterionic materials for various applications such as membranes, drug delivery, and sensors.