Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia
Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia
复制标题
DOI：
10.1016/s0920-9964(00)00137-7
复制
发表时间：
2001-05-30
影响因子：
4.5
通讯作者：
Martinot, JL
中科院分区：
文献类型：
--
作者：
Paillère-Martinot, ML;Caclin, A;Martinot, JL
很少有精神分裂症的磁共振成像研究调查了发病年龄较早的患者的脑组织体积及其与临床症状的关系。这项研究的双重目的是调查灰色和白色物质的体积在精神分裂症的男性与早期发病的年龄，并确定是否与组织体积的变化，使用自动体素的体素图像分析程序的临床特征。20例男性患者与DSM-IV诊断的精神分裂症，并在发病年龄（m +/- SD = 19 +/- 2）与20个年龄匹配的健康男性进行了比较。使用反转恢复准备的快速梯度回波序列获得磁共振（1.5-T）扫描，增强灰色和白色物质对比度。统计参数映射用于图像分割和比较。患者的额内侧回、左侧海马、左侧海马旁灰质明显减少。和左侧梭状回;还观察到额叶双侧白色物质减少和脑脊液总量增加。阴性症状评分与扣带回区和右侧内囊的白色物质体积呈负相关。这些发现强调了左半球灰质异常的模式，并表明额边缘连接可能会改变男性早发性精神分裂症。(C)2001 Elsevier Science B. V.保留所有权利。
Few magnetic resonance imaging studies of schizophrenia have investigated brain tissue volumes and their relation to clinical symptoms in patients with an early age at illness onset. The twofold purpose of the study was to investigate both gray and white matter volumes in schizophrenic men with an early age at illness onset, and to determine whether clinical features correlated with tissue volume changes, using an automated voxel-by-voxel image analysis procedure. Twenty male patients with DSM-IV diagnoses of schizophrenia, and an early age at onset (m +/- SD = 19 +/- 2) were compared with 20 age-matched health men. Magnetic resonance (1.5-T) scans were obtained with an Inversion-Recovery prepared fast gradient echo sequence enhancing gray and white matter contrast. Statistical Parametric Mapping was used for image segmentation and comparison. Patients had significant gray matter reductions in medial frontal gyri, left insula, left parahippocampus. and left fusiform gyrus; bilateral white matter reductions in frontal lobes, and increased total cerebrospinal fluid volume were also observed. Negative symptom scores were negatively related to white matter volumes in cingulate regions, and in the right internal capsule. These findings emphasize a pattern of left-hemisphere gray matter abnormalities, and suggest that fronto-paralimbic connectivity may be altered in men with early onset schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.