Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases
Accumulation of IL-17-Positive Cells in Decidua of Inevitable Abortion Cases
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DOI：
10.1111/j.1600-0897.2010.00812.x
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Saito, Shigeru
中科院分区：
文献类型：
--
作者：
Nakashima, Akitoshi;Ito, Mika;Saito, Shigeru
ProblemTh 17细胞是辅助性T细胞的一个新的亚群，已被关注为促炎细胞因子的产生者。然而，目前还不清楚Th 17细胞如何影响妊娠结局。为探讨IL-17产生细胞在自然流产中的表达，采用免疫组化和流式细胞术检测了正常妊娠、稽留流产和难免流产患者蜕膜组织中IL-17的表达。难免流产伴生殖道活动性出血组蜕膜IL-17+细胞数明显高于正常妊娠组（P < 0.05）。而稽留流产组和正常妊娠组蜕膜IL-17阳性细胞数无显著性差异。结论IL-17+细胞在自然流产晚期可能参与炎症反应，但在自然流产早期可能不参与炎症反应。
ProblemTh17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion.Method of studyIL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.ResultsIL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases.ConclusionIL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.