Characterising the prevalence of overweight and obese status among adults with sickle cell disease.
Characterising the prevalence of overweight and obese status among adults with sickle cell disease.
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描述患有镰状细胞病的成年人中超重和肥胖状况的患病率。
DOI：
10.1111/bjh.18548
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发表时间：
2023
影响因子：
6.5
通讯作者：
Tana
中科院分区：
文献类型：
--
作者：
Ibemere,StephanieO;Oyedeji,CharityI;Preiss,Liliana;VanAlthuis,LauraE;Hankins,JaneS;Azul,Melissa;Burns,EbonyN;Glassberg,Jeffrey;Hagar,Ward;Hussain,Faiz;King,Allison;Melvin,Cathy;Myers,John;Snyder,Angela;Shah,Nirmish;Tana
患有镰状细胞病（SCD）的人历来被认为体重过轻。尽管一般人群的体重指数（BMI）不断增加，但成人SCD人群中超重和肥胖状态的患病率仍不清楚。我们的主要目的是确定超重和肥胖状态的患病率，并确定BMI，人口统计学和临床特征之间的关联。我们对镰状细胞病实施联盟登记处的抽象电子健康记录数据和患者报告的结果进行了分析;包括20-45岁的个体。本分析中1664名成人的中位（四分位距）BMI为23.9（21.1-28）kg/m2。在该队列中，42.9%的BMI>25 kg/m2（疾病控制和预防中心对超重/肥胖的定义）。在多变量分析中，超重或肥胖的几率与女性性别、年龄、大学教育、私人保险和高血压诊断有关。HbSC或HbSβ+地中海贫血患者BMI>25 kg/m2的几率较高，与未暴露于羟基脲的HbSS或HbS β 0地中海贫血患者相比，无论是否暴露于羟基脲（羟基脲）（比值比[OR] 3.4，p <0.0001）和暴露于羟基脲的HbSS或HbS β 0地中海贫血患者（OR 1.6，p = 0.0003）。这些数据强调了早期识别、预防和干预增加BMI以减少可能影响SCD相关并发症的肥胖相关并发症的重要性。
Individuals with sickle cell disease (SCD) have historically been considered underweight. Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associations between BMI, demographic, and clinical characteristics. We conducted an analysis of abstracted electronic health record data and patient‐reported outcomes from the Sickle Cell Disease Implementation Consortium registry; individuals aged 20–45 years were included. The median (interquartile range) BMI for the 1664 adults in this analysis was 23.9 (21.1–28) kg/m2. In this cohort, 42.9% had a BMI of >25 kg/m2(Centers for Disease Control and Prevention definition of overweight/obese). In multivariable analysis, higher odds of being overweight or obese were associated with female gender, older age, college education, private insurance, and hypertension diagnosis. Higher odds of a BMI of >25 kg/m2were observed in individuals with HbSC or HbSβ+thalassaemia regardless of hydroxycarbamide (hydroxyurea) exposure (odds ratio [OR] 3.4,p< 0.0001) and HbSS or HbSβ0thalassaemia exposed to hydroxycarbamide (OR 1.6,p= 0.0003) compared to those with HbSS or HbSβ0thalassaemia with no hydroxycarbamide exposure. These data highlight the importance of early identification, prevention, and intervention for increasing BMI to reduce obesity‐related complications that may impact SCD‐related complications.