Intraobserver and interobserver reproducibility in the evaluation of optic disc stereometric parameters by Heidelberg Retina Tomograph
Intraobserver and interobserver reproducibility in the evaluation of optic disc stereometric parameters by Heidelberg Retina Tomograph
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DOI：
10.1016/s0161-6420(02)01032-1
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发表时间：
2002-06-01
期刊：
影响因子：
13.7
通讯作者：
Orzalesi, N
中科院分区：
文献类型：
--
作者：
Miglior, S;Albé, E;Orzalesi, N
目的：评价Heidelberg视网膜层析成像（HRT）测量视盘立体参数在观察者内和观察者间的再现性。研究设计：观察性研究，观察者间可变性。参与者：55名志愿者（健康受试者和青光眼患者）。方法：55例患者1只眼连续3天重复视盘HRT检查。在每次会议期间，由两个独立的观察者随机获取五张单个图像。然后在每次会议上建立一个基于三张单幅图像的平均地形图像（MTI）。对于观察者内部图像评估，两个观察者在一个随机选择的MTI上追踪他们自己的等高线。这个过程重复了三次。对于观察者内部图像间和观察者内部/图像间的评估，两个观察者在第一个会话的MTI上绘制自己的等高线，然后自动叠加到其他两个会话的MTI上。主要观察指标：通过类内相关系数（ICC）计算每个观察者的12个立体参数的可重复性。两次独立评估之间的可变性预期范围由每次测试-重测差异相对于其平均值的散点图计算。用均数重测分数差异的标准差来描述分数差异的分布。结果：观察者内部图像的ICC范围为0.79至0.99，观察者内部图像间评估的ICC范围为0.56至1。观察者间图像的ICC介于0.54和0.99之间，观察者间图像评估的ICC介于0.65和0.97之间。对于平面测量，ICC几乎完美到完美（0.81 < ICC小于或等于1），对于体积和杯形测量，ICC几乎完美（0.61 < ICC小于或等于0.99），对于视网膜神经纤维层相关测量，ICC几乎完美（0.41 < ICC < 0.99）。预期变异性较低(95%置信区间，
Purpose: To assess intraobserver and interobserver reproducibility of the measurement of stereometric parameters of the optic disc by means of the Heidelberg Retina Tomograph I (HRT).Study design: Observational study, with interobserver variability.Participants: Fifty-five volunteers (healthy subjects and patients with glaucoma).Methods: HRT examination of the optic disc was repeated on 3 consecutive days on 1 eye of each of the 55 subjects. During each session, five single images were randomly acquired by two independent observers. One mean topography image (MTI), based on three single images, was then built at each session. For the intraobserver intraimage evaluation, the two observers traced their own contour line on one randomly chosen MTI. This procedure was repeated three times. For the intraobserver interimage and interobserver intra/interimage evaluations, the two observers traced their own contour line on the MTI of the first session, which was then automatically superimposed on the MTls of the other two sessions.Main Outcome Measures: Reproducibility of the 12 stereometric parameters was calculated for each observer by means of the intraclass correlation coefficient (ICC). The expected range of variability between two independent evaluations was calculated by the scatter-plots of each test-retest difference versus their mean. The standard deviation of the mean test-retest score differences was used to describe the spread of score differences.Results: The ICC ranged between 0.79 and 0.99 for intraobserver intraimage and between 0.56 and 1 for intraobserver interimage evaluation. The ICC ranged between 0.54 and 0.99 for interobserver intraimage and between 0.65 and 0.97 for the interobserver interimage evaluation. ICC was almost perfect to perfect for planimetric measures (0.81 < ICC less than or equal to 1), substantial to almost perfect for volumetric and cup measures (0.61 < ICC less than or equal to 0.99), and moderate to almost perfect for retinal nerve fiber layer related measures (0.41 < ICC < 0.99). The expected variability was low (95% confidence interval,