Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1.
Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1.
复制标题
DOI：
10.18632/oncotarget.24792
复制
发表时间：
2018-04-10
期刊：
影响因子：
--
通讯作者：
Matarrese P
中科院分区：
文献类型：
--
作者：
Ciarlo L;Vona R;Manganelli V;Gambardella L;Raggi C;Marconi M;Malorni W;Sorice M;Garofalo T;Matarrese P
线粒体动力学的调节以及融合和分裂过程之间的平衡对细胞的健康和命运至关重要。线粒体融合和分裂机制由关键蛋白控制，如有丝分裂蛋白、OPA-1和其他几个分子。在本工作中，我们研究了脂筏在MDIVI-1诱导的线粒体融合中的作用。我们的结果强调了脂质“筏”在线粒体形态发生变化及其动态平衡中的可能意义。
The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid “rafts” in mitochondrial morphogenetic changes and their homeostasis.