Cytokine-Targeted Therapeutics for KSHV-Associated Disease.
Cytokine-Targeted Therapeutics for KSHV-Associated Disease.
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DOI：
10.3390/v12101097
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发表时间：
2020-09-28
期刊：
影响因子：
--
通讯作者：
Totonchy J
中科院分区：
文献类型：
--
作者：
Alomari N;Totonchy J
卡波西肉瘤相关疱疹病毒（Kaposi's sarcoma-associated herpesvirus，KSHV）又称人类疱疹病毒8型（human herpesvirus 8，HHV-8），与多种人类恶性肿瘤有关，包括卡波西肉瘤（Kaposi's sarcoma，KS）、原发性渗出性淋巴瘤（primary effusion lymphoma，PEL）、多中心Castleman病（multicentric Castleman's disease，MCD）和最近的KSHV炎性细胞因子综合征（inflammatory cytokine syndrome，KICS）。与其他具有显著炎症成分的疾病一样，目前对KSHV相关疾病的治疗与显著的脱靶效应相关。然而，我们对KSHV发病机制的理解的最新进展产生了新的见解，使用细胞因子作为潜在的治疗靶点。更好地了解细胞因子在KSHV感染和肿瘤发生过程中的作用，可能会导致新的预防或治疗策略，以限制KSHV的传播和改善临床结果。作为KSHV抗病毒疗法的有希望的候选者的细胞因子包括白细胞介素6、10和12以及干扰素和肿瘤坏死因子家族细胞因子。这篇综述探讨了我们目前对细胞因子在促进KSHV感染和肿瘤发生中所起作用的认识，并总结了目前使用细胞因子作为KSHV相关疾病的治疗靶点。
Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS). As with other diseases that have a significant inflammatory component, current therapy for KSHV-associated disease is associated with significant off-target effects. However, recent advances in our understanding of the pathogenesis of KSHV have produced new insight into the use of cytokines as potential therapeutic targets. Better understanding of the role of cytokines during KSHV infection and tumorigenesis may lead to new preventive or therapeutic strategies to limit KSHV spread and improve clinical outcomes. The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. This review explores our current understanding of the roles that cytokines play in promoting KSHV infection and tumorigenesis, and summarizes the current use of cytokines as therapeutic targets in KSHV-associated diseases.
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