SARS-CoV-2 Host Immunogenetic Biomarkers.
SARS-CoV-2 Host Immunogenetic Biomarkers.
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SARS-CoV-2 宿主免疫遗传生物标志物。
DOI：
10.1007/978-1-0716-2395-4_10
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Mayne,ElizabethS
中科院分区：
文献类型：
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作者：
Gededzha,MaemuP;Mampeule,Nakampe;Gandini,Anastasia;Mayne,ElizabethS
SARS-CoV-2 通常引起轻微症状，大约 10-20% 的病例进展为严重疾病。 SARS-CoV-2 引起严重疾病的病理生理机制在很大程度上尚不清楚。数据表明不同的免疫遗传标记（例如 HLA、T 和 B 细胞）的参与与疾病结果相关。这引发了人们对这些基因作为 SARS-CoV-2 易感性的潜在生物标志物以及用于预测预后以及对疫苗和其他治疗策略的反应的兴趣。在本章中，我们讨论了表征这些潜在生物标志物的概要方案以及使用 Luminex®100/200 技术和新一代测序识别 SARS-CoV-2 生物标志物的方法。
SARS-CoV-2 causes generally mild symptoms, with approximately 10–20% of cases progressing to severe disease. The pathophysiologic mechanisms by which SARS-CoV-2 causes severe disease are largely unknown. Data have indicated the involvement of different immunogenetic markers such as HLA, T, and B cells, to be associated with disease outcome. This has led to interest in these genes as potential biomarkers of SARS-CoV-2 susceptibility and for predicting prognosis and response to vaccines and other therapeutic strategies. In this chapter, we discussed outline protocols for characterizing these potential biomarkers and methods for identifying SARS-CoV-2 biomarkers using the Luminex®100/200 technology and next-generation sequencing.