The role of performance factors in the active avoidance-conditioning deficit in autoimmune mice.
The role of performance factors in the active avoidance-conditioning deficit in autoimmune mice.
复制标题
表现因素在自身免疫小鼠主动回避调节缺陷中的作用。
DOI：
10.1037//0735-7044.110.3.486
复制
发表时间：
1996
影响因子：
1.9
通讯作者：
Crnic,LS
中科院分区：
文献类型：
--
作者：
Schrott,LM;Crnic,LS
先前对自身免疫小鼠的研究表明，与自身免疫程度相关的双向主动回避条件反射存在缺陷。在这项研究中，自身免疫雌性NZB× NZW F1杂交（B/W）小鼠在休克激发的辨别学习，单向回避条件反射，和修改的双向回避任务进行了测试，并与非自身免疫雌性NZW小鼠进行了比较。辨别和单向条件反射的结果表明，B/W小鼠可以学习冲击动机的任务，涉及最小的疲劳和没有冲突。B/W小鼠也能够学习双向回避任务时，它更容易通过增加条件刺激线索的显着性，澄清意外事件，并增加试验间隔，以减少可能的认知，情绪和身体疲劳。因此，在双向回避表现不佳似乎是改变注意力，动机，或情绪的结果，可以通过改变任务参数来克服。（PsycInfo数据库记录（c）2024阿帕，保留所有权利）
Prior studies with autoimmune mice demonstrated deficits in 2-way active avoidance conditioning that correlated with the degree of autoimmunity. In this study, autoimmune female NZB× NZW F1 hybrid (B/W) mice were tested in shock-motivated discrimination learning, 1-way avoidance conditioning, and a modified 2-way avoidance task and compared to nonautoimmune female NZW mice. The discrimination and 1-way conditioning results indicated that B/W mice can learn shock-motivated tasks that involve minimal fatigue and no conflict. B/W mice were also able to learn the 2-way avoidance task when it was made easier by increasing conditioned-stimulus cue salience, clarifying contingencies, and increasing trial spacing to decrease possible cognitive, emotional, and physical fatigue. Thus, poor performance in 2-way avoidance appears to be a consequence of altered attention, motivation, or emotionality and can be overcome by altering task parameters.(PsycInfo Database Record (c) 2024 APA, all rights reserved)