Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
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芳香族脒：比较它们阻断呼吸道合胞病毒诱导的细胞融合和抑制纤溶酶、尿激酶、凝血酶和胰蛋白酶的能力。
DOI：
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发表时间：
1983
影响因子：
7.3
通讯作者：
E. Dubovi
中科院分区：
文献类型：
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作者：
R. Tidwell;J. Geratz;E. Dubovi
研究了由24个化合物组成的两个酰胺衍生物系列对呼吸道合胞病毒诱导的细胞融合的阻断作用与对选定的胰蛋白酶样蛋白酶的抑制活性之间的相关性。虽然这两个活动之间没有明显的相关性，但还是有一些潜在的重要发现。获得了一种高选择性的纤溶酶优于凝血酶的抑制剂（化合物10），并鉴定了一种有效的病毒诱导细胞融合的新阻断剂（化合物22）。
Two series of amidine derivatives consisting of a total of 24 compounds were examined for a correlation between their blocking effect on respiratory syncytial virus induced cell fusion and their inhibitory activity against selected trypsin-like protease. Although no correlation was evident between the two activities, several potentially important discoveries were made. A highly selective inhibitor of plasmin over thrombin (compound 10) was obtained, and a potent new blocker of virus-induced cell fusion (compound 22) was identified.