Splitsville: structural and functional insights into the dynamic bacterial Z ring.
Splitsville: structural and functional insights into the dynamic bacterial Z ring.
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DOI：
10.1038/nrmicro.2016.26
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Margolin W
中科院分区：
文献类型：
--
作者：
Haeusser DP;Margolin W
细菌必须分裂，以增加数量和殖民他们的生态位。二分裂是细菌细胞分裂最普遍的方式，但即使是这种相对简单的机制也显示出许多变化。在大多数细菌中，微管蛋白同系物FtsZ在胞质分裂位点组装成环状结构（Z环），并招募额外的蛋白质形成跨越膜的大型蛋白质机器（分裂体）。在这里，我们讨论了目前的见解调节Z环组装和分裂体如何驱动膜内陷和隔细胞壁生长，同时仍然灵活地响应各种细胞输入。
Bacteria must divide in order to increase in number and colonize their niche. Binary fission is the most widespread means of bacterial cell division, but even this relatively simple mechanism displays many variations on a theme. In most bacteria, the tubulin homolog FtsZ assembles into a ring structure (Z ring) at the site of cytokinesis and recruits additional proteins to form a large protein machine (divisome) that spans the membrane. Here we discuss current insights into the regulation of Z ring assembly and how the divisome drives membrane invagination and septal cell wall growth while still flexibly responding to various cellular inputs.