Acellular Spinal Cord Scaffold Seeded With Bone Marrow Stromal Cells Protects Tissue and Promotes Functional Recovery in Spinal Cord-Injured Rats
Acellular Spinal Cord Scaffold Seeded With Bone Marrow Stromal Cells Protects Tissue and Promotes Functional Recovery in Spinal Cord-Injured Rats
复制标题
接种骨髓基质细胞的无细胞脊髓支架可保护脊髓损伤大鼠的组织并促进功能恢复
DOI：
10.1002/jnr.23311
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发表时间：
2014-03-01
影响因子：
4.2
通讯作者：
Jin, Dadi
中科院分区：
文献类型：
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作者：
Chen, Jian;Zhang, Zhongmin;Jin, Dadi
使用接种有干细胞的支架的治疗在脊髓损伤（SCI）的修复中起着重要作用，移植的细胞分化成神经细胞以取代失去的组织，同时释放有助于SCI后修复的神经营养因子并增强受损神经系统的功能。本研究探讨了骨髓基质细胞（BMSCs）移植到无细胞脊髓（ASC）支架上，以延长BMSCs的存活时间，恢复受损的脊髓和促进功能恢复的能力。BBB评分显示，与单独使用ASC支架或未处理的对照组相比，将BMSC接种到ASC支架中的治疗导致运动功能恢复的明显改善。这种改善在术后2周和8周明显（P
Therapy using scaffolds seeded with stem cells plays an important role in repair of spinal cord injury (SCI), with the transplanted cells differentiating into nerve cells to replace the lost tissue while releasing neurotrophic factors that contribute to repair following SCI and enhance the function of the damaged nervous system. The present study investigated the ability to extend the survival time of bone marrow stromal cells (BMSCs) to restore the damaged spinal cord and improve functional recovery by grafting acellular spinal cord (ASC) scaffold seeded or not with BMSCs in a rat model of acute hemisected SCI. BBB scores revealed that treatment with BMSCs seeded into ASC scaffold led to an obvious improvement in motor function recovery compared with treatment with ASC scaffold alone or untreated controls. This improvement was evident at 2 and 8 weeks after surgery (P