EFFECTS OF ANTIFLAMMINS ON ENDOTOXIN-INDUCED UVEITIS IN RATS
EFFECTS OF ANTIFLAMMINS ON ENDOTOXIN-INDUCED UVEITIS IN RATS
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DOI：
10.1001/archopht.1991.01080020124058
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发表时间：
1991-02-01
影响因子：
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通讯作者：
NUSSENBLATT, RB
中科院分区：
文献类型：
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作者：
CHAN, CC;NI, M;NUSSENBLATT, RB
抗炎蛋白是磷脂酶A2抑制性、抗炎性、合成的寡肽，来源于子宫珠蛋白和脂皮质素I之间氨基酸序列相似性最高的区域。 内毒素诱导的葡萄膜炎是眼睛前葡萄膜炎的模型，其已被认为是通过磷脂酶A2活化诱导的。 在一份初步报告中，我们证明了局部给药抗炎蛋白可以抑制大鼠内毒素诱导的葡萄膜炎。 在这项研究中，抗炎药的抗炎作用进行了比较与皮质类固醇激素对内毒素诱导的葡萄膜炎的磷脂酶A2酶活性，炎性细胞计数在房水中，和组织病理学特征。 抗炎素在抑制内毒素诱导的葡萄膜炎方面与皮质类固醇一样有效。
Antiflammins are phospholipase A2-inhibitory, anti-inflammatory, synthetic oligopeptides derived from the region of the highest amino-acid sequence similarity between uteroglobin and lipocortin I. Endotoxin-induced uveitis is a model for anterior uveitis of the eye, which has been suggested to be induced through phospholipase A2 activation. In a preliminary report we demonstrated that topical administration of antiflammins could inhibit endotoxin-induced uveitis in rats. In this study, the anti-inflammatory effects of antiflammins were compared with those of corticosteroids on endotoxin-induced uveitis as measured by phospholipase A2 enzyme activity, inflammatory cell counts in the aqueous humor, and histopathologic features. Antiflammins are as effective as corticosteroids in their ability to suppress endotoxin-induced uveitis.