Designed formation of Prussian Blue/CuS Janus nanostructure with enhanced NIR-I and NIR-II dual window response for tumor thermotherapy
Designed formation of Prussian Blue/CuS Janus nanostructure with enhanced NIR-I and NIR-II dual window response for tumor thermotherapy
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DOI：
10.1016/j.jcis.2022.01.074
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发表时间：
2022-01-19
影响因子：
9.9
通讯作者：
Dong, Xiangting
中科院分区：
文献类型：
--
作者：
Li, Dan;Wang, Tingting;Dong, Xiangting
设计具有增强的光热转换效率（PCE）的光热转换剂（PTA）对于光热肿瘤根除应用具有至关重要的意义。目前，通过设计能级跃迁增强紫外吸收是提高光热效率的有效途径。为了解决这一难题，我们通过在聚丙烯酸纳米颗粒（PB NPs）的一个表面上选择性地涂覆聚丙烯酸纳米半球，然后在聚丙烯酸模板上进一步形成硫化铜，开发了新型的普鲁士蓝聚丙烯酸/硫化铜Janus纳米颗粒（PB@PAA/CuS JNPs）。实验结果表明，在Janus结构之间发生了能级跃迁。此外，它提供了增强的吸收比NIR-I和NIR-II双窗口。肌肉组织渗透研究表明，PB@PAA/CuS JNPs在1064 nm激光照射组中具有更深的组织渗透，表明其治疗深部组织定位肿瘤的潜力。总之，独特的PB@PAA/CuS JNPs在NIR-I和NIR-II双窗口上显示出增强的肿瘤抑制作用，这将为通过合理的PTA纳米结构设计来提高PTT效率开辟新的机会。(c)2022年由Elsevier Inc.出版
Designing photothermal transducing agents (PTAs) with enhanced photothermal conversion efficiency (PCE) holds essential importance for photothermal tumor eradication applications. Currently, it is an effective way to improve the photothermal efficiency by designing the energy level transition leading to the enhancement of UV absorption. To address the challenge, we develop novel Prussian blue@polyacrylic acid/copper sulfide Janus nanoparticles (PB@PAA/CuS JNPs) via selective coating of PAA nanohemisphere on one of the surfaces of PB NPs followed by the further formation of CuS on the PAA template. The experiments show that the energy level transition occurs between Janus structure. Besides, it offers enhanced absorption over NIR-I and NIR-II dual windows. The muscle tissue penetration studies suggest that the PB@PAA/CuS JNPs have deeper tissue penetration in the 1064 nm laser irradiation group, indicating their potential for treating deep-tissue-seated tumors. In a word, the unique PB@PAA/CuS JNPs show an enhanced tumor inhibitory effect over the NIR-I and NIR-II dual windows, which will open up new opportunities for improving PTT efficiency by the rational nanostructural design of PTAs. (c) 2022 Published by Elsevier Inc.