Near-infrared spectroscopy for monitoring muscle oxygenation
Near-infrared spectroscopy for monitoring muscle oxygenation
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DOI：
10.1046/j.1365-201x.2000.00713.x
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发表时间：
2000-04-01
期刊：
影响因子：
--
通讯作者：
Piantadosi, CA
中科院分区：
文献类型：
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作者：
Boushel, R;Piantadosi, CA
近红外光谱（NIRS）是一种非侵入性的方法，用于监测组织的氧可用性和利用率。在完整的骨骼肌中，NIRS允许半定量测量血红蛋白加肌红蛋白氧合（组织O-2储存）和血红蛋白体积。专门的算法允许评估线粒体细胞色素c氧化酶的铜部分（CuA）的氧化还原（氧化还原）状态，并使用特定的示踪剂，准确评估局部血流。近红外光谱已被证明可用于监测次极量和极量运动期间以及包括心血管疾病和败血症在内的病理生理条件下肌肉氧合和血流的变化。工作期间，骨骼肌脱氧的程度根据肌肉类型、运动类型和血流反应而有所不同。在某些情况下，一个强大的一致性之间的下降，在O-2商店与增量工作和减少在铜的氧化态。然而，在某些病理条件下，O-2储存和氧化还原状态的变化可能有很大的分歧。
Near-infrared spectroscopy (NIRS) is a non-invasive method for monitoring oxygen availability and utilization by the tissues. In intact skeletal muscle, NIRS allows semi-quantitative measurements of haemoglobin plus myoglobin oxygenation (tissue O-2 stores) and the haemoglobin volume. Specialized algorithms allow assessment of the oxidation-reduction (redox) state of the copper moiety (CuA) of mitochondrial cytochrome c oxidase and, with the use of specific tracers, accurate assessment of regional blood flow. NIRS has demonstrated utility for monitoring changes in muscle oxygenation and blood flow during submaximal and maximal exercise and under pathophysiological conditions including cardiovascular disease and sepsis. During work, the extent to which skeletal muscles deoxygenate varies according to the type of muscle, type of exercise and blood flow response. In some instances, a strong concordance is demonstrated between the fall in O-2 stores with incremental work and a decrease in CuA oxidation state. Under some pathological conditions, however, the changes in O-2 stores and redox state may diverge substantially.