Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock
Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock
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DOI：
10.1186/1471-2334-2-26
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发表时间：
2002-10-31
影响因子：
3.7
通讯作者：
Felek, S
中科院分区：
文献类型：
--
作者：
Celik, I;Akbulut, A;Felek, S
背景：尽管脓毒性休克的治疗取得了重大进展，但死亡率仍在逐步上升。布洛芬已被证明在治疗时具有有益的生理效果。然而，关于生存，有相互矛盾的结果。本研究旨在探讨布洛芬对内源性休克兔生命功能、各项生理参数及生存的影响。方法：28只新西兰兔随机分为4组。第一组只给予生理盐水，第二组在t(0)时静脉给予2 mg/kg内毒素，第三组在内毒素给药后30分钟给予30 mg/kg布洛芬，第四组在内毒素给药前30分钟给予布洛芬。记录呼吸、心率、平均动脉血压和直肠温度。在前两个小时进行全血细胞计数，每30分钟测量一次血栓素B-2，然后在整个实验过程中每小时测量一次。在同一时间点采集尿样，测定前列腺素E-2。结果：布洛芬可改善呼吸频率、心率和动脉压。然而，它并没有改善内毒素对体温、红细胞压积值、白细胞计数和血小板数量的负面影响。IV组血栓素B-2水平明显低于其他组，且升高开始时间较晚。在接受布洛芬治疗的动物中，前列腺素E-2水平至少在90分钟内保持在低位，但此后开始上升。II组的平均生存时间为192.9 +/- 46.9 min， III组和IV组的平均生存时间分别为339.1 +/- 33.5 min （p < 0.05）和383.0 +/- 39.6 min （p = 0.01）。结论：布洛芬可以提高内源性休克动物的存活率。因此，它可能有助于预防和治疗患有或可能发展为感染性休克的患者。
Background: Despite major developments in the management of septic shock, the mortality rate had progressively increased. Ibuprofen has been shown to have beneficial physiological effects when used as a treatment. However, there are conflicting results with respect to survival. This study aims to investigate the effect of ibuprofen on vital functions, various physiological parameters and survival during endotoxic shock in rabbits.Methods: Twenty-eight New Zealand rabbits were randomly separated into four groups. The first group received only saline, the second was given 2 mg/kg intravenous endotoxin at t(0), the third received 30 mg/kg ibuprofen 30 minutes after endotoxin administration, whilst the fourth group received ibuprofen 30 minutes before the endotoxin. Respiratory and heart rate, mean arterial blood pressure and rectal temperature were recorded. Complete blood counts were performed and thromboxane B-2 was measured every 30 minutes for the first two hours, and then hourly over the course of the experiment. Urine samples were collected at the same time points for the measurement of prostaglandin E-2.Results: Ibuprofen was found to improve respiratory rate, heart rate, and arterial pressure. However, it did not improve the negative effects of endotoxin on body temperature, haematocrit values, white blood cell count, and thrombocyte number. Thromboxane B-2 levels in group IV were significantly lower than in the other groups, and the increase started at a later timepoint. In ibuprofen-treated animals, Prostaglandin E-2 levels stayed low for at least 90 minutes, but started to rise thereafter. While the average survival in Group II animals was 192.9 +/- 46.9 minutes, those of groups III and IV were 339.1 +/- 33.5 minutes (p < 0.05) and 383.0 +/- 39.6 minutes (p = 0.01), respectively.Conclusions: Ibuprofen appears to increase survival in endotoxic shock-induced animals. Therefore, it may be helpful for the prophylaxis and treatment of patients with, or who are likely to develop, septic shock.