One-Pot Synthesis of α-Carbolines via Sequential Palladium-Catalyzed Aryl Amination and Intramolecular Arylation
One-Pot Synthesis of α-Carbolines via Sequential Palladium-Catalyzed Aryl Amination and Intramolecular Arylation
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DOI：
10.1021/jo802776m
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发表时间：
2009-04-17
影响因子：
3.6
通讯作者：
Cuny, Gregory D.
中科院分区：
文献类型：
--
作者：
Laha, Joydev K.;Petrou, Philip;Cuny, Gregory D.
本文描述了一种通过钯催化的芳基胺化反应和分子内芳基化反应一锅法合成α-咔啉的方法。2，3-二氯-和2，3-二溴吡啶已显示与容易获得的苯胺反应，以中等至优异的产率获得各种取代的α-咔啉。
A one-pot synthesis of alpha-carbolines via a palladium-catalyzed aryl amination followed by intramolecular arylation is described. 2,3-Dichloro- and 2,3-dibromopyridines have been shown to react with readily available anilines to obtain various substituted alpha-carbolines in moderate to excellent yields.