Chalcone-analogue fluorescent prfobes for saccharides signaling using the boronic acid group
Chalcone-analogue fluorescent prfobes for saccharides signaling using the boronic acid group
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DOI：
10.1016/s0040-4039(02)00312-x
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发表时间：
2002-04-01
影响因子：
1.8
通讯作者：
Lakowicz, JR
中科院分区：
文献类型：
--
作者：
DiCesare, N;Lakowicz, JR
报道了两种新的基于1，3-二苯基-2-烯-1-酮和1，5-二苯基-2，4-二烯-1-酮结构的荧光探针。两种探针均含有一个给电子基和一个硼酸基(吸电子基团)。在高pH和/或糖存在下，硼酸基的中性和阴离子形式之间的变化导致了这两种探针的光学变化。给出了不同单糖的光谱数据、pK(A)和离解常数，并从糖检测的角度进行了讨论。(C)2002爱思唯尔科学有限公司。保留所有权利。
Two new fluorescent probes based on 1,3-diphenylprop-2-en-1-one and on 1,5-diphenylpenta-2,4-dien-1-one structures are presented. Both probes posses one electron-donating dimethylamino group and one boronic acid group (electron-withdrawing group). The change between the neutral and the anionic form of the boronic acid group induced at high pH and/or in presence of sugar, induces optical changes for both probes. Spectroscopic data, pK(a) and dissociation constants for different monosaccharides are presented and discussed in terms of sugar detection. (C) 2002 Elsevier Science Ltd. All rights reserved.