Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons
Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons
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DOI：
10.1023/a:1021946210399
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发表时间：
1997-12-01
影响因子：
4.4
通讯作者：
Nishiyama, N
中科院分区：
文献类型：
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作者：
Moriguchi, T;Matsuura, H;Nishiyama, N
大蒜提取物中发现的几种有机硫化合物促进了大鼠海马神经元的体外存活。从构效关系分析，这些化合物中的硫丙基对神经营养活性的表现至关重要。大蒜提取物中含有硫丙基的有机硫化合物s -烯丙基- l-半胱氨酸（SAG）也能促进培养神经元的轴突分支。这些结果表明，硫代烯丙基化合物构成了一组独特的神经营养因子。
Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAG), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.