eIF3d: A driver of noncanonical cap-dependent translation of specific mRNAs and a trigger of biological/pathological processes.
eIF3d: A driver of noncanonical cap-dependent translation of specific mRNAs and a trigger of biological/pathological processes.
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DOI：
10.1016/j.jbc.2023.104658
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发表时间：
2023-05
影响因子：
4.8
通讯作者：
Zhang, Jian-Ting
中科院分区：
文献类型：
--
作者：
Ma, Shijie;Liu, Jing-Yuan;Zhang, Jian-Ting
真核起始因子3d（eIF 3d）是eIF 3复合物的已知RNA结合亚基，是具有RNA结合基序和帽结合结构域的66至68-kDa蛋白。与其他eIF 3亚基相比，eIF 3d的研究相对较少。然而，最近在研究eIF 3d方面的进展揭示了一些有趣的发现，它在维持eIF 3复合物的完整性，全球蛋白质合成，以及在生物和病理过程中的作用。也有报道称，eIF 3d通过与5′-UTR结合或与不依赖于eIF 3复合物的其他蛋白质相互作用，在调节mRNA亚类的翻译方面具有非经典功能，并在调节蛋白质稳定性方面具有额外功能。mRNA翻译或蛋白质稳定性的非经典调节可能有助于eIF 3d在生物学过程中的作用，如代谢应激适应和疾病的发生和进展，包括严重急性呼吸综合征冠状病毒2型感染，肿瘤发生和获得性免疫缺陷综合征。本文就eIF 3d在这些方面的研究进展进行综述，并对eIF 3d在蛋白质合成调控以及生物学和病理学过程中的作用进行展望。
Eukaryotic initiation factor 3d (eIF3d), a known RNA-binding subunit of the eIF3 complex, is a 66 to 68-kDa protein with an RNA-binding motif and a cap-binding domain. Compared with other eIF3 subunits, eIF3d is relatively understudied. However, recent progress in studying eIF3d has revealed a number of intriguing findings on its role in maintaining eIF3 complex integrity, global protein synthesis, and in biological and pathological processes. It has also been reported that eIF3d has noncanonical functions in regulating translation of a subset of mRNAs by binding to 5′-UTRs or interacting with other proteins independent of the eIF3 complex and additional functions in regulating protein stability. The noncanonical regulation of mRNA translation or protein stability may contribute to the role of eIF3d in biological processes such as metabolic stress adaptation and in disease onset and progression including severe acute respiratory syndrome coronavirus 2 infection, tumorigenesis, and acquired immune deficiency syndrome. In this review, we critically evaluate the recent studies on these aspects of eIF3d and assess prospects in understanding the function of eIF3d in regulating protein synthesis and in biological and pathological processes.
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影响因子：
64.5
作者：
Erzberger JP;Stengel F;Pellarin R;Zhang S;Schaefer T;Aylett CHS;Cimermančič P;Boehringer D;Sali A;Aebersold R;Ban N
通讯作者：
Ban N
影响因子：
16
作者：
Ciesla, Maciej;Phuong Cao Thi Ngoc;Bellodi, Cristian
通讯作者：
Bellodi, Cristian
DOI：
10.1098/rstb.2016.0176
发表时间：
2017-03-19
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
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作者：
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通讯作者：
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影响因子：
16
作者：
Guan BJ;van Hoef V;Jobava R;Elroy-Stein O;Valasek LS;Cargnello M;Gao XH;Krokowski D;Merrick WC;Kimball SR;Komar AA;Koromilas AE;Wynshaw-Boris A;Topisirovic I;Larsson O;Hatzoglou M
通讯作者：
Hatzoglou M
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影响因子：
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作者：
Jiang M;Lu Y;Duan D;Wang H;Man G;Kang C;Abulimiti K;Li Y
通讯作者：
Li Y