Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms.
Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms.
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发表时间：
2001-09
期刊：
影响因子：
11.2
通讯作者：
M. Zlatescu;Ali Reza TehraniYazdi;Hikaru Sasaki;Joseph F. Megyesi;R. Betensky;David N. Louis;J. Cairncross
中科院分区：
文献类型：
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作者：
M. Zlatescu;Ali Reza TehraniYazdi;Hikaru Sasaki;Joseph F. Megyesi;R. Betensky;David N. Louis;J. Cairncross
间变性少突胶质细胞瘤的分子遗传学亚群在生物学上表现不同，包括它们的生长速度和对标准疗法的反应。在一系列的64例病例中，我们评估了染色体臂1 p和19 q的等位基因丢失，这是化学敏感性少突胶质细胞瘤发生的早期分子事件，是否与肿瘤的位置和肿瘤在大脑中的扩散程度有关。我们观察到肿瘤基因型与肿瘤部位密切相关（P < 0.001）。位于额叶、顶叶和枕叶的间变性少突胶质细胞瘤比发生在颞叶、中脑和间脑的组织学上难以区分的肿瘤更可能具有染色体臂1 p和19 q的等位基因丢失（P < 0.001）。此外，1 p和19 q的杂合性丢失与双侧生长模式显著相关（P = 0.037）;所有7例双侧分布的间变性少突胶质细胞瘤均存在1 p和19 q等位基因丢失。因此，我们的结论是，少突胶质细胞瘤的分子亚型可能优先出现在某些脑叶，并有不同的生长模式，与肿瘤的等位基因丢失的染色体1 p和19 q发生在额叶最频繁，并有一个广泛的增长的趋势，在中线。这些发现鼓励调查的生物学基础，这种显着的差异，并已对目前的管理这些肿瘤的影响。
Molecular genetic subsets of anaplastic oligodendroglioma behave in biologically distinct ways, in both their rates of growth and their responses to standard therapies. In a series of 64 cases, we evaluated whether allelic loss of chromosomal arms 1p and 19q, an early molecular event in the genesis of chemosensitive oligodendrogliomas, is related to tumor location and extent of tumor spread in the brain. We observed that tumor genotype was closely associated with tumor location (P < 0.001). Anaplastic oligodendrogliomas located in the frontal, parietal, and occipital lobes were significantly more likely to harbor allelic loss of chromosomal arms 1p and 19q than histologically indistinguishable tumors arising in the temporal lobe, insula, and diencephalon (P < 0.001). In addition, loss of heterozygosity for 1p and 19q was significantly associated with a bilateral pattern of growth (P = 0.037); all seven bilaterally distributed anaplastic oligodendrogliomas had 1p and 19q allelic loss. We conclude, therefore, that molecular subtypes of oligodendrogliomas may arise preferentially in certain lobes of the brain and have differential patterns of growth, with tumors having allelic loss of chromosomes 1p and 19q occurring most frequently in the frontal lobes and having a tendency for widespread growth across the midline. These findings encourage inquiries into the biological basis of such marked differences and already have implications for the current management of these neoplasms.