Highly enantioselective deracemization of linear and vaulted biaryl ligands.
Highly enantioselective deracemization of linear and vaulted biaryl ligands.
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线性和拱形联芳基配体的高度对映选择性去消旋化。
DOI：
10.1021/ol0275769
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发表时间：
2003
期刊：
影响因子：
5.2
通讯作者：
Wulff,WilliamD
中科院分区：
文献类型：
--
作者：
Zhang,Yu;Yeung,Siu-Man;Wu,Hongqiao;Heller,DouglasP;Wu,Chunrui;Wulff,WilliamD
在(−)-Sartiene存在下，铜可以很容易地实现拱形联芳基配体VANOL和VAPOL的去消旋化。优化的工艺包括原位生成铜(II)，并从外消旋体中可重复地生成(S)-VANOL和(S)-VAPOL。该方法优于现有的BINOL方法(92%ee)。
A copper-mediated deracemization of the vaulted biaryl ligands VANOL and VAPOL can be readily achieved in the presence of (−)-spartiene. The optimal procedure involves the in situ generation of copper(II) and leads to the reproducible formation of (S)-VANOL and (S)-VAPOL in greater than 99% ee from the racemates. This method is superior to existing procedures for BINOL (92% ee).