SKELETAL-MUSCLE UTILIZATION OF FREE FATTY-ACIDS IN WOMEN WITH VISCERAL OBESITY
SKELETAL-MUSCLE UTILIZATION OF FREE FATTY-ACIDS IN WOMEN WITH VISCERAL OBESITY
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DOI：
10.1172/jci117864
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发表时间：
1995-04-01
影响因子：
15.9
通讯作者：
KELLEY, DE
中科院分区：
文献类型：
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作者：
COLBERG, SR;SIMONEAU, JA;KELLEY, DE
内脏性肥胖与胰岛素抵抗密切相关。一个潜在的原因是FFA的可用性增加。或者，有人提出，在有肥胖风险的个体中存在脂质氧化受损，这两个概念涉及骨骼肌的程度是不确定的，为了检验这些相反的假设，17名健康的瘦和肥胖的绝经前妇女，其中内脏脂肪的横截面积范围为18至180 cm（2），参与腿部平衡研究，以测量基础和胰岛素刺激条件下FFA和葡萄糖利用率。在通过经皮活检获得的股外侧肌中，基于酶活性确定骨骼肌的代谢谱。内脏脂肪含量与胰岛素敏感性呈负相关（腿部葡萄糖摄取和储存率），但胰岛素抵抗不是由葡萄糖-FFA竞争引起的。在高胰岛素血症期间，内脏型肥胖妇女腿部FFA摄取和氧化均未增加。腿部FFA摄取率与内脏肥胖呈负相关，肌肉肉毒碱棕榈酰转移酶和柠檬酸合酶的活性也是如此，总之，内脏肥胖与骨骼肌胰岛素抵抗明显相关，但这不是由于葡萄糖-FFA底物竞争，相反，内脏肥胖女性的肌肉吸收后FFA利用率降低。
Visceral obesity is strongly associated with insulin resistance. One potential cause is increased availability of FFA. Alternatively, it has been proposed that there is impaired oxidation of lipid in individuals at risk for obesity, The extent to which either concept involves skeletal muscle is uncertain, To examine these opposing hypotheses, 17 healthy lean and obese premenopausal women, among whom cross-sectional area of visceral fat ranged from 18 to 180 cm(2), participated in leg balance studies for measurement of FFA and glucose utilization during basal and insulin-stimulated conditions, A metabolic profile of skeletal muscle, based on enzyme activity, was determined in vastus lateralis muscle obtained by percutaneous biopsy. Visceral fat content was negatively correlated with insulin sensitivity (rates of leg glucose uptake and storage), but insulin resistance was not caused by glucose-FFA competition, During hyperinsulinemia, neither leg FFA uptake nor oxidation was increased in women with visceral obesity, During fasting conditions, however, rates of FFA uptake across the leg were negatively correlated with visceral adiposity as were activities of muscle carnitine palmitoyl transferase and citrate synthase, In summary, visceral adiposity is clearly associated with skeletal muscle insulin resistance but this is not due to glucose-FFA substrate competition, Instead, women with visceral obesity have reduced postabsorptive FFA utilization by muscle.