AGE-RELATED MACULAR CHANGES IN HUMANS OVER 90 YEARS OLD
AGE-RELATED MACULAR CHANGES IN HUMANS OVER 90 YEARS OLD
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DOI：
10.1016/s0002-9394(14)74549-0
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发表时间：
1990-03-15
影响因子：
4.2
通讯作者：
GAO, CL
中科院分区：
文献类型：
--
作者：
FEENEYBURNS, L;BURNS, RP;GAO, CL
用光镜和电子显微镜检查了23例90 ~ 101岁供体的黄斑，并与49 ~ 68岁供体的黄斑进行了比较。评估中央凹光感受器和视网膜色素上皮细胞的数量，黄斑色素的存在和脂褐素荧光。年龄相关性黄斑变性的典型病理特征出现在90- 101岁年龄组中的9例，其变化范围从早期新生血管到完全发育的盘状疤痕、地理萎缩和黄斑孔。一些视网膜色素上皮细胞和光感受器细胞数量与年轻组相同，但大多数出现细胞丢失。增厚，充满碎屑的布鲁氏膜和绒毛膜毛细血管萎缩虽然常见，但并不是老年的必然伴随。临床医生应告知老年患者，他们维持黄斑结构和功能的机会大于50%。
The macula lutea of 23 donors aged 90 to 101 years were examined by light and electron microscopy and compared to maculas from a 49- to 68-year-old age group. The number of foveal photreceptors and retinal pigment epithelial cells, the presence of macular pigment, and lipofuscin fluorescence were assessed. Pathologic characteristics typical of age-related macular degeneration occurred in nine of the 90- to 101-year-old group with changes ranging from early neovascularization to fully developed disciform scars, geographic atrophy, and macular holes. Several retinas had pigment epithelial and photoreceptor cell numbers equal to those of the younger group, but most showed cell loss. Thickened, debris-filled Bruch''s membrane and choriocapillary atrophy, although common, were not an invariable accompaniment to old age. Clinicians should advise elderly patients that their chances of maintaining macular structure, and hopefully function, are better than 50%.