Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: An in vitro study
Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: An in vitro study
复制标题
DOI：
10.1016/j.materresbull.2013.05.059
复制
发表时间：
2013-09-01
影响因子：
5.4
通讯作者：
Vincent, S.
中科院分区：
文献类型：
--
作者：
Arokiyaraj, S.;Saravanan, M.;Vincent, S.
本研究旨在通过化学方法合成氧化铁纳米颗粒，并对其进行表征和抗菌活性评价。叶提取物IO-NP的形成通过颜色变化证实，并通过紫外-可见光谱进一步检查。用SEM和TEM表征了产物的形貌，结果表明产物为球形，粒径在10 ~ 30 nm之间，晶粒大小均匀。XRD图谱中的峰与面心立方型铁氧化物纳米颗粒的峰非常一致。FT-IR光谱证实了植物活性分子在IO-NPs表面的附着。此外，针对大肠杆菌MTCC 443、奇异变形杆菌MTCC 425和枯草芽孢杆菌MTCC 441筛选IO-NP、植物提取物和用植物提取物处理的IO-NP的抗菌功效。结果表明，该菌株对奇异变形杆菌和大肠杆菌有明显的抑制作用。大肠杆菌与IO-NPs处理的植物提取物。这一结果可能为利用磁性纳米粒子作为药物载体系统治疗细菌性疾病铺平道路。(c)2013爱思唯尔有限公司保留所有权利。
The present study intended for the chemical synthesis of iron oxide nanoparticles (IO-NPs) followed by characterization and evaluation of antibacterial activity after treating with Argemone mexicana L. leaf extract. The formation of IO-NPs was confirmed by the colour change and further examined by UV-vis spectroscopy. The morphology was characterized by using SEM and TEM, which showed spherical particles of uniform size ranged between 10 and 30 nm and the crystallites were determined through XRD. The peaks in XRD pattern are in good agreement with that of face-centered cubic form of iron oxide nanoparticles. FT-IR spectroscopy confirmed the attachment of bioactive molecules of plant on the IO-NPs surfaces. Furthermore, the antibacterial efficacy of IO-NPs, plant extract and IO-NPs treated with plant extract was screened against Escherichia coli MTCC 443, Proteus mirabilis MTCC 425 and Bacillus subtilis MTCC 441. The results showed a noteworthy inhibition on P. mirabilis and E. coli with IO-NPs treated plant extract. This outcome may pave a way for using the magnetic nanoparticles as a drug carrier system to cure bacterial diseases. (c) 2013 Elsevier Ltd. All rights reserved.