Directional Recording of Subthalamic Spectral Power Densities in Parkinson's Disease and the Effect of Steering Deep Brain Stimulation
Directional Recording of Subthalamic Spectral Power Densities in Parkinson's Disease and the Effect of Steering Deep Brain Stimulation
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DOI：
10.1016/j.brs.2015.02.002
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发表时间：
2015-07-01
影响因子：
7.7
通讯作者：
Contarino, M. F.
中科院分区：
文献类型：
--
作者：
Bour, L. J.;Lourens, M. A. J.;Contarino, M. F.
背景资料：一种新的32触点脑深部电刺激（DBS）电极，能够定向转向刺激，在术中进行了测试。目的：这项初步研究的目的是进行记录从多向接触，并探讨定向电流转向对局部场电位（LFPs）的影响。方法：在8名帕金森病患者中，经过标准微电极记录和临床测试后，临时植入了新电极导线。32通道LFP记录，同时测量在不同的深度和方向之前和之后的定向stimulation.Results：LFPs功率谱密度的空间分布在整个接触阵列在基线标记的边界的丘脑底核（ESTA）与β功率的显着增加，平均精度约为0.6毫米，在4名患者。在所有患者中，18.5-30 Hz频带中的功率在不同方向上变化。在显示刚性改善的三种情况下，当电流被引导向β带中具有最高LFP功率的方向时，刚性更高。6例患者的丘脑底核LFPs在四种不同的“转向”模式后，与环模式相比，在10-45 Hz频带内的振荡活动表现出不同的频率依赖性抑制/增强，这表明特异性更高。通过一种新的32触点DBS电极导线，可以在不同深度和方向同时记录丘脑底LFP，提供适当导线放置的确认和可能与病理性丘脑底电活动和刺激效果相关的多方向时空信息。虽然还需要进一步的研究，但这可能会提高转向刺激的效率。(C)2015 Elsevier Inc. All rights reserved.
Background: A new 32-contacts deep brain stimulation (DBS) lead, capable of directionally steering stimulation, was tested intraoperatively.Objective: The aim of this pilot study was to perform recordings from the multidirectional contacts and to investigate the effect of directional current steering on the local field potentials (LFPs).Methods: In eight patients with Parkinson's disease, after standard microelectrode recording and clinical testing, the new lead was temporarily implanted. The 32-channel LFP recordings were measured simultaneously at different depths and directions before and after directional stimulation.Results: The spatial distribution of LFPs power spectral densities across the contact array at baseline marked the borders of the subthalamic nucleus (STN) with a significant increase in beta power and with a mean accuracy of approximately 0.6 mm in four patients. The power in the 18.5-30 Hz frequency band varied across different directions in all patients. In the three cases that showed improvement of rigidity, this was higher when current was steered toward the direction with the highest LFP power in the beta band. Subthalamic LFPs in six patients showed a differential frequency-dependent suppression/enhancement of the oscillatory activity in the 10-45 Hz frequency band after four different 'steering' modes as compared to ring mode, suggesting a higher specificity.Conclusions: Through a new 32-contact DBS lead it is possible to record simultaneous subthalamic LFPs at different depths and directions, providing confirmation of adequate lead placement and multidirectional spatial-temporal information potentially related to pathological subthalamic electrical activity and to the effect of stimulation. Although further research is needed, this may improve the efficiency of steering stimulation. (C) 2015 Elsevier Inc. All rights reserved.