Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype.
Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype.
复制标题
急性劳拉西泮给药对正常老年受试者胺能活性的影响：与性能影响和载脂蛋白基因型的关系。
DOI：
10.1023/b:nere.0000026402.09466.54
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发表时间：
2004
影响因子：
4.4
通讯作者：
Lajtha,Abel
中科院分区：
文献类型：
--
作者：
Pomara,Nunzio;Willoughby,LisaM;Hashim,Audrey;Sershen,Henry;Sidtis,JohnJ;Wesnes,Keith;Greenblatt,DavidJ;Lajtha,Abel
研究了急性劳拉西泮激发对血浆（p）HVA、MHPG和5-HIAA的影响，以及它们与药物诱导的认知和运动缺陷以及载脂蛋白（APOE）-ε4等位基因的关系。18名健康老年人（8名ε4携带者）随机接受安慰剂或急性口服劳拉西泮剂量（0.5 mg或1 mg），间隔1周。在基线和攻毒后1、2.5和5 h测定认知评估和血浆pHVA、pMHPG和p5-HIAA水平。无论ε4状态如何，单胺水平均无药物与安慰剂之间的差异，单胺水平变化与认知能力之间无一致性关系。然而，1.0 mg剂量增加了ε4携带者中的p5-HIAA，而它导致非携带者减少。较高的基线pMHPG和p5-HIAA水平与较好的基线记忆相关。ε4等位基因可能调节劳拉西泮对p5-HIAA的作用，但需要进一步的研究来证实这一发现并阐明其可能的意义。
The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-ε4 allele were examined. Eighteen healthy elderly (8 ε4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) in random sequence, 1-week apart. Cognitive assessment and plasma levels of pHVA, pMHPG, and p5-HIAA were determined at baseline and at 1, 2.5, and 5 h postchallenge. There was no drug-to-placebo difference in monoamine levels and no consistent relationship between changes in monoamine levels and cognitive performance, regardless of ε4 status. However, the 1.0 mg dose increased p5-HIAA in ε4 carriers, whereas it caused a reduction in noncarriers. Higher baseline pMHPG and p5-HIAA levels were associated with better baseline memory. The ε4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance.