Identification of cancer hallmark-associated gene and lncRNA cooperative regulation pairs and dictate lncRNA roles in oral squamous cell carcinoma
Identification of cancer hallmark-associated gene and lncRNA cooperative regulation pairs and dictate lncRNA roles in oral squamous cell carcinoma
复制标题
癌症标志相关基因和lncRNA协同调控配对的鉴定并决定lncRNA在口腔鳞状细胞癌中的作用
DOI：
10.1111/jcmm.15174
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发表时间：
2020-03-23
影响因子：
5.3
通讯作者：
He, Yong-Wen
中科院分区：
文献类型：
--
作者：
Lin, Ken;Song, Lin-Jing;He, Yong-Wen
口腔鳞状细胞癌（OSCC）是口腔和上颌面区域中最常见的恶性肿瘤。许多癌症具有十个普通特征（“标志”），这些特征控制正常细胞向癌细胞的转化。长的非编码RNA（LNCRNA）是导致肿瘤发生的重要因素。但是，对于OSCC中LNCRNA与癌症标志相关基因之间的合作关系知之甚少。通过对癌症标志，体突变，拷贝数变体（CNV）和表达的综合分析，确定了一些OSCC特异性癌症相关基因和LNCRNA。根据突变的共表达和共同发生，开发了一个与不同癌症标志相关的基因和lncRNA合作调节对（GLCRP）的计算框架。 OSCC中表征了十个基于GLCRP的癌症标志的独特和常见特征。 OSCC中，大多数GLCRP共享对抗流流信号和生长信号自给自足的不敏感性。一些关键的GLCRP参与OSCC的许多癌症标志。与癌症相关的GLCRP网络在OSCC中具有复杂的模式和特定功能。特别是，一些关键的GLCRP与OSCC患者的预后有关。总而言之，我们生成了与癌症标志相关的GLCRP的全面景观，可以作为未来功能探索的起点，在OSCC中鉴定生物标志物和基于LNCRNA的靶向治疗。
Oral squamous cell carcinoma (OSCC) is the most common malignant tumour in the oral and maxillofacial region. Numerous cancers share ten common traits ("hallmarks") that govern the transformation of normal cells into cancer cells. Long non-coding RNAs (lncRNAs) are important factors that contribute to tumorigenesis. However, very little is known about the cooperative relationships between lncRNAs and cancer hallmark-associated genes in OSCC. Through integrative analysis of cancer hallmarks, somatic mutations, copy number variants (CNVs) and expression, some OSCC-specific cancer hallmark-associated genes and lncRNAs are identified. A computational framework to identify gene and lncRNA cooperative regulation pairs (GLCRPs) associated with different cancer hallmarks is developed based on the co-expression and co-occurrence of mutations. The distinct and common features of ten cancer hallmarks based on GLCRPs are characterized in OSCC. Cancer hallmark insensitivity to antigrowth signals and self-sufficiency in growth signals are shared by most GLCRPs in OSCC. Some key GLCRPs participate in many cancer hallmarks in OSCC. Cancer hallmark-associated GLCRP networks have complex patterns and specific functions in OSCC. Specially, some key GLCRPs are associated with the prognosis of OSCC patients. In summary, we generate a comprehensive landscape of cancer hallmark-associated GLCRPs that can act as a starting point for future functional explorations, the identification of biomarkers and lncRNA-based targeted therapy in OSCC.