De novo formal synthesis of (-)-virginiamycin M2 via the asymmetric hydration of dienoates.
De novo formal synthesis of (-)-virginiamycin M2 via the asymmetric hydration of dienoates.
复制标题
通过二烯酸酯的不对称水合从头正式合成 (-)-维吉尼亚霉素 M2。
DOI：
10.1021/ol071145e
复制
发表时间：
2007
期刊：
影响因子：
5.2
通讯作者：
O'Doherty,GeorgeA
中科院分区：
文献类型：
--
作者：
Mortensen,MatthewS;Osbourn,JoshuaM;O'Doherty,GeorgeA
A de novo approach to the formal total synthesis of the macrolide natural product (−)-virginiamycin M2has been achieved via a convergent approach. The absolute and relative stereochemistry of the nonpeptide portion of (−)-virginiamycin M2was introduced by two Sharpless asymmetric dihydroxylation reactions.
