Post-transcriptional control of mitochondrial protein composition in changing environmental conditions.
Post-transcriptional control of mitochondrial protein composition in changing environmental conditions.
复制标题
DOI：
10.1042/bst20200250
复制
发表时间：
2020-12-18
影响因子：
3.9
通讯作者：
Zid BM
中科院分区：
文献类型：
--
作者：
Tsuboi T;Leff J;Zid BM
在波动的环境条件下，生物体必须调节它们的生物能生产，以维持细胞内稳态以获得最佳适应性。线粒体是代谢物和能量产生的枢纽。线粒体在功能上也是高度动态的：调节其组成、大小、密度和与细胞代谢需求相关的网络状结构。在这里，我们回顾了最近的研究线粒体组成的转录后调控集中在mRNA定位，mRNA翻译，蛋白质进口，以及动态线粒体结构可能对这些基因表达过程中的作用。由于线粒体的结构和功能已被证明对年龄相关的过程非常重要，包括癌症，代谢紊乱和神经变性，了解线粒体组成如何在波动条件下受到影响可以导致新的治疗方向。
In fluctuating environmental conditions, organisms must modulate their bioenergetic production in order to maintain cellular homeostasis for optimal fitness. Mitochondria are hubs for metabolite and energy generation. Mitochondria are also highly dynamic in their function: modulating their composition, size, density, and the network-like architecture in relation to the metabolic demands of the cell. Here, we review the recent research on the post-transcriptional regulation of mitochondrial composition focusing on mRNA localization, mRNA translation, protein import, and the role that dynamic mitochondrial structure may have on these gene expression processes. As mitochondrial structure and function has been shown to be very important for age-related processes, including cancer, metabolic disorders, and neurodegeneration, understanding how mitochondrial composition can be affected in fluctuating conditions can lead to new therapeutic directions to pursue.