Avian homologues of mammalian intralaminar, mediodorsal and midline thalamic nuclei: immunohistochemical and hodological evidence.
Avian homologues of mammalian intralaminar, mediodorsal and midline thalamic nuclei: immunohistochemical and hodological evidence.
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哺乳动物层内、内侧和中线丘脑核的鸟类同源物：免疫组织化学和方法学证据。
DOI：
10.1159/000112983
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Reiner,A
中科院分区：
文献类型：
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作者：
Veenman,CL;Medina,L;Reiner,A
本文介绍并回顾了一些数据，这些数据表明鸟类的背侧丘脑区（缩写为 DTZ）与哺乳动物的层内、中线和内侧丘脑核复合体（缩写为 IMMC）同源。 DTZ位于鸟类间脑的背内侧，由几个亚核组成：丘脑背内侧前核（DMA）、丘脑背内侧后核（DMP）、丘脑背外侧核、内侧部（DLM）、丘脑背中间后核（DIP）、丘脑背外侧核(DLP) 和缰核外侧核 (SHL)。我们的免疫组化研究表明：（1）SHL以及DMA和DMP的内侧和背侧部分相对富含GABA能、含脑啡肽、含P物质和胆碱能纤维； (2) DMA和DMP的侧向部分这些神经递质含量相对较差； (3)DIP、DLP和DLM适度富含胆碱能纤维和含P物质的纤维。我们的逆行通路追踪研究表明，DTZ 更外侧部分的 DIP 和 DLP 投射到体细胞纹状体，而 DMA、DMP 和 SHL 位于 DTZ 更内侧投射到内脏/边缘纹状体。我们的顺行追踪研究表明，DIP 接收来自背侧苍白球的传入信号，而 DMA 和 DMP 似乎接收来自腹侧纹状体和腹侧苍白球的传入信号。先前的多项研究表明，一般来说，DTZ 的内侧和外侧部分分别与内脏/边缘和躯体脑区域相关。这些特征表明：（1）SHL以及DMA和DMP的内侧和背侧部分与哺乳动物中线丘脑核团相当，包括层内核团的内侧成分； (2) DMA和DMP的外侧部分与哺乳动物的背内侧核相当； (3) DIP与哺乳动物的束旁核相当； (4) DLM 和 DLP 与哺乳动物中位于外侧的层内核相当。鸟类 DTZ 和哺乳动物 IMMC 的相似性表明，它们是从常见爬行动物祖先中存在的丘脑前体核进化而来的，并且它们可能在基底神经节的运动控制功能中发挥相似的作用。
This paper presents and reviews data suggesting that the dorsal thalamic zone (abbreviated DTZ) in birds is homologous to the intralaminar, midline, and mediodorsal thalamic nuclear complex (abbreviated IMMC) in mammals. The DTZ is located dorsomedially in the diencephalon of birds and consists of several subnuclei: nucleus dorsomedialis anterior thalami (DMA), nucleus dorso-medialis posterior thalami (DMP), nucleus dorsolateralis anterior thalami, pars medialis (DLM), nucleus dorsointermedius posterior thalami (DIP), nucleus dorsolateralis posterior thalami (DLP), and nucleus subhabenularis lateralis (SHL). Our immunohistochemical studies show that: (1) SHL and medial and dorsal parts of DMA and DMP are relatively rich in GABAergic, enkephalin-containing, substance P-containing, and cholinergic fibers; (2) lateral parts of DMA and DMP are relatively poor in these neurotransmitters; and (3) DIP, DLP, and DLM are moderately rich in cholinergic and substance P-containing fibers. Our retrograde pathway tracing studies indicate that the DIP and DLP in the more lateral parts of DTZ project to somatic striatum, while the DMA, DMP, and SHL located more medially in the DTZ project to visceral/limbic striatum. Our anterograde tracing studies indicate that DIP receives afferents from the dorsal pallidum, whereas DMA and DMP appear to receive afferents from both the ventral striatum and ventral pallidum. Diverse prior studies have shown that in general medial and lateral components of DTZ are connected with visceral/ limbic and somatic brain regions, respectively. These characteristics indicate that: (1) SHL and medial and dorsal parts of DMA and DMP are comparable to mammalian midline thalamic nuclei, including the medial components of the intralaminar nuclei; (2) lateral parts of DMA and DMP are comparable to the mediodorsal nucleus in mammals; (3) DIP is comparable to the parafascicular nucleus in mammals; and (4) DLM and DLP are comparable to the laterally located intralaminar nuclei in mammals. The comparability of avian DTZ and mammalian IMMC suggests that they evolved from thalamic precursor nuclei present in the common reptilian ancestors and that they may perform similar roles in the movement control function of the basal ganglia.