Adult metformin ingestions reported to Texas poison control centers, 2000-2006
Adult metformin ingestions reported to Texas poison control centers, 2000-2006
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DOI：
10.1177/0960327108090589
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发表时间：
2008-07-01
影响因子：
2.8
通讯作者：
Forrester, M. B.
中科院分区：
文献类型：
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作者：
Forrester, M. B.
二甲双胍是一种用于治疗2型糖尿病的口服降糖药。关于报告给中毒控制中心的成人二甲双胍的信息有限。根据各种因素确定了2000-2006年期间向德克萨斯州中毒控制中心报告的成人二甲双胍的分布。此外，还起草了隔离性传染病管理的分诊准则。在总共1528次二甲双胍摄入中，58%涉及辅助摄入剂。在264例二甲双胍单药摄入中，最终医学结局已知，66%报告了摄入的剂量。平均报告剂量为4739 mg（范围500- 60，000 mg）。报告剂量为5000 mg的摄入量在涉及疑似自杀未遂（6%与81%）、严重最终医学结局（3%与19%）和转诊至医疗机构（3%与83%）的比例方面存在差异。使用5000毫克作为转诊到医疗机构的阈值剂量，91%的病例尚未到达或正在前往医疗机构的途中，根据起草的分流指南进行了管理。
Metformin is an oral hypoglycemic agent used in the management of type 2 diabetes mellitus. Limited information exists on adult metformin ingestions reported to poison control centers. The distribution of adult metformin ingestions reported to Texas poison control centers during 2000-2006 was determined for various factors. In addition, triage guidelines for the management of isolated ingestions were drafted. Of 1528 total metformin ingestions, 58% involved coingestants. Of the 264 ingestions of metformin alone, where the final medical outcome was known, dose ingested was reported for 66%. The mean reported dose was 4739 mg (range 500-60,000 mg). Ingestions of 5000 mg reported doses differed with respect to the proportion involving suspected attempted suicide (6% versus 81%), serious final medical outcome (3% versus 19%), and referral to a health care facility (3% versus 83%). Using 5000 mg as a threshold dose for referral to a health care facility, 91% of cases not already at or en route to a health care facility were managed according drafted triage guidelines.