Local field potential recordings from the pedunculopontine nucleus in a Parkinsonian patient
Local field potential recordings from the pedunculopontine nucleus in a Parkinsonian patient
复制标题
DOI：
10.1097/wnr.0b013e3282f2e2d1
复制
发表时间：
2008-01-08
期刊：
影响因子：
1.7
通讯作者：
Gill, Steven S.
中科院分区：
文献类型：
--
作者：
Androulidakis, Alexandros G.;Khan, Sadaquate;Gill, Steven S.
桥脑脚核最近被引入作为帕金森病患者，特别是那些有严重步态和姿势障碍的患者进行脑深部刺激的新靶点。该部位的刺激通常以低频进行，而丘脑底核则需要高频刺激才能获得治疗效果。因此，我们寻找并证明了帕金森病患者桥小脑脚核活动的低频同步性证据，这种同步性在多巴胺治疗后增加，并可能被低频的局部脑深部刺激所模拟。
The pedunculopontine nucleus has recently been introduced as a new therapeutic target for deep brain stimulation in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. Therefore, we looked for and demonstrated evidence of low frequency synchronization of activity in the pedunculopontine nucleus of a patient with Parkinson's disease that increased after treatment with dopamine and which might be mimicked by local deep brain stimulation at low frequency.