Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis
Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis
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DOI：
10.1080/20002297.2017.1374154
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发表时间：
2017-09-10
影响因子：
4.5
通讯作者：
Holmstrup, Palle
中科院分区：
文献类型：
--
作者：
Damgaard, Christian;Reinholdt, Jesper;Holmstrup, Palle
目的：作为牙周炎和心血管疾病(CVD)的标志物，研究伴生放线杆菌和牙龈卟啉单胞菌的循环抗体水平是否与牙周附着丧失有关。设计：来自丹麦健康体检调查(DANHES)576名参与者的血清。结果：单因素Logistic回归分析表明，抗牙周炎放线菌抗体(OR=1.48)和伴生放线菌抗体(1.31)与牙周炎相关。这些抗体水平也分别与心血管疾病相关(1.17和1.37)，然而，在使用多变量Logistic回归分析调整了其他危险因素，包括年龄、吸烟、性别、饮酒、超重和教育水平后，只有增加体重指数(BMI；1.09)、既往吸烟(1.99)和年龄增加(几十年)(2.27)仍与心血管疾病相关。结论：在单因素分析中，心血管疾病和牙周炎与Pg抗体水平或伴生放线菌抗体水平相关，但在调整常见混杂因素后，只有Pg抗体水平与牙周炎有统计学意义。年龄尤其影响了这段关系。
Objectives: The aim was to elucidate whether levels of circulating antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD).Design: Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of A. actinomycetemcomitans and P. gingivalis were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria.Results: Levels of antibodies against P. gingivalis (OR = 1.48) and A. actinomycetemcomitans (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level of education using multivariable logistic regression analysis, only increasing body mass index (BMI; 1.09), previous smoking (1.99), and increasing age (decades) (2.27) remained associated with CVD. Increased levels of antibodies against P. gingivalis (1.34) remained associated with periodontitis after adjusting for other risk factors.Conclusions: CVD and periodontitis were associated with levels of IgG antibodies to P. gingivalis or A. actinomycetemcomitans in univariable analyses, but only the association of P. gingivalis antibody levels with periodontitis reached statistical significance after adjustment for common confounders. Age, in particular, influenced this relationship.