Effects of amifostine on radiation-induced cardiac damage
Effects of amifostine on radiation-induced cardiac damage
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DOI：
10.1080/0891060310002168
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发表时间：
2003-01-01
期刊：
影响因子：
3.1
通讯作者：
Wondergem, J
中科院分区：
文献类型：
--
作者：
Kruse, JJCM;Strootman, EG;Wondergem, J
本研究的目的是探讨在照射前给予氨磷汀是否能减轻大鼠心脏的辐射损伤。将雌性Spraque-Dawley大鼠随机分配至心脏局部接受单次剂量照射（0-22.5戈伊）。在辐射暴露前15至20分钟，动物接受腹膜内给予氨磷汀（160 mg/kg）或缓冲盐水溶液。照射后6个月，通过体外工作大鼠心脏制备评估心脏功能。使用半定量评分系统评估大鼠心脏不同解剖区域的间质和/或血管周围纤维化的严重程度。剂量大于或接近20戈伊的辐射暴露显著降低冠状动脉流量、主动脉流量和心输出量。放疗前给予氨磷汀可保护患者免受这些影响，即使在22.5戈伊照射后，仍能维持正常的心输出量。在用氨磷汀处理的动物中，组织学损伤（即血管周围纤维化和间质纤维化）的小的、不显著的减少也是明显的。氨磷汀对心脏照射野肺组织肉眼可见损伤的严重程度和范围有明显的保护作用。这项研究的结果表明，在照射前给予单剂量的氨磷汀可有效减少心脏损伤。
The purpose of this study was to investigate whether administration of amifostine prior to irradiation could reduce radiation damage of the rat heart. Female Spraque-Dawley rats were randomized to receive single-dose irradiation (0-22.5 Gy) locally to the heart. Fifteen to twenty minutes before radiation exposure, the animals received either intraperitoneally administered amifostine (160 mg/kg) or buffered saline solution. At 6 months post-irradiation, cardiac function was assessed by the in vitro working rat heart preparation. The severity of interstitial and/or perivascular fibrosis in different anatomical regions of the rat heart was assessed using a semi-quantitative scoring system. Radiation exposure to doses greater than or similar to 20 Gy markedly reduced coronary flow, aortic flow and cardiac output. Administration of amifostine prior to radiotherapy afforded protection against these effects and normal cardiac output was maintained, even after 22.5 Gy. A small, non-significant, reduction in histological damage (i.e. perivascular fibrosis and interstitial fibrosis) was also apparent in animals treated with amifostine. There was a clear protective effect of amifostine on the severity and extent of macroscopic damage in lung tissue included in the cardiac irradiation field. The findings of this study suggest that a single dose of amifostine administered prior to irradiation is effective in reducing cardiac damage.