Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke
Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke
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DOI：
10.1097/01.wcb.0000100044.07481.97
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发表时间：
2003-12-01
影响因子：
6.3
通讯作者：
Alvarez-Sabín, J
中科院分区：
文献类型：
--
作者：
Montaner, J;Rovira, A;Alvarez-Sabín, J
研究了16例急性大脑中动脉卒中患者的神经炎症标志物与灌注和弥散加权磁共振成像（MRI）病变体积（PWI和DWI）的相关性。在到达时（少于6小时），连续测量（通过ELISA）血浆基质金属蛋白酶（MMP）-9，MMP-2，白细胞介素（IL）-6，IL-8，细胞间粘附分子（ICAM）-1和肿瘤坏死因子（TNF）-α，并进行MRI检查。在脑缺血中，组织破坏似乎与基质金属蛋白酶表达相关，因为基线MMP-9是DWI病变测量的梗死体积的唯一预测因子（线性回归：B = 0.50，0.25-0.74; P < 0.001）。此外，低灌注脑区（PWI）的程度与接下来几个小时内促炎细胞因子（TNF-α和IL-6）的释放相关。
Sixteen patients with acute middle cerebral artery stroke were studied to correlate neuroinflammatory markers with perfusion- and diffusion-weighted magnetic resonance imaging (MRI) lesion volumes (PWI and DWI). At arrival (less than 6 hours), plasmatic matrix metalloproteinase (MMP)-9, MMP-2, interleukin (IL)-6, IL-8, intercellular adhesion molecule (ICAM)-1, and tumor necrosis factor (TNF)-alpha were serially measured (by ELISA), and MRI was performed. In cerebral ischemia, tissue destruction seems related to matrix metalloproteinases expression because baseline MMP-9 was the only predictor of the infarct volume measured as a DWI lesion (lineal regression: b = 0.50, 0.25-0.74; P < 0.001). Moreover, the extent of hypoperfused brain area (PWI) was associated with a proinflammatory cytokine release in the next hours (TNF-alpha and IL-6).